PMID: 2501002Jun 12, 1989Paper

Microglial response to 6-hydroxydopamine-induced substantia nigra lesions

Brain Research
H Akiyama, P L McGeer

Abstract

Major histocompatibility complex (MHC) antigen and glial fibrillary acidic protein (GFA) expression in rat brain was observed following 6-hydroxydopamine (6-OHDA)-induced lesions to the nigrostriatal tract. MHC class I and class II antigen expression was observed on cells, morphologically identified as monocytes/macrophages, at the injection site. MHC class I and class II antigen expression was also observed on reactive microglia, particularly in the region of degenerating SN neurons, but also along the nigrostriatal tract. Class I expression was more vigorous than class II. MHC class I expression appeared by day 1 and class II by day 4. Peak MHC expression occurred between day 6 and day 10. It subsided as healing took place and had largely disappeared by day 30. GFA expression in reactive astrocytes, on the other hand, developed early but was still prominent by day 90. MHC expression is reflective of immune system activity and occurs in conjunction with neuronal injury and disappearance. GFA expression is reflective of residual astrocytic scarring and remains after phagocytotic activity has been completed. Combined observation of these markers in diseased brain tissue can provide clues as to the stage of the pathology being ob...Continue Reading

References

Jun 1, 1979·European Journal of Immunology·W R McMaster, A F Williams
Jan 1, 1988·Acta Neuropathologica·P L McGeerE G McGeer
Oct 1, 1988·Annals of Neurology·P L McGeerE G McGeer

❮ Previous
Next ❯

Citations

Feb 1, 1994·Cellular and Molecular Neurobiology·A KlegerisS A Greenfield
Aug 25, 2004·Neurotoxicity Research·Ananth ChandrasekaranCharanjit Kaur
Sep 1, 2004·Cell and Tissue Research·Peter Teismann, Jörg B Schulz
Feb 5, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fabio Blandini
Jun 25, 2009·Neurotoxicity Research·Mika ShimojiItalo Mocchetti
May 22, 1992·Brain Research. Developmental Brain Research·M OhnoK Suzuki
Sep 17, 1993·Brain Research. Developmental Brain Research·K NagataS Kohsaka
Jan 1, 1990·Neuroscience·J M LawrenceG Raisman
May 12, 2005·Parkinsonism & Related Disorders·Etienne C HirschAndreas Hartmann
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I PodkletnovaH Alho
Oct 1, 1995·Neuropathology and Applied Neurobiology·C KaurE A Ling
Oct 13, 2011·Journal of Neuroinflammation·Janelle Drouin-OuelletFrancesca Cicchetti
Aug 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jae-Kyung LeeMalú G Tansey
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui-Ming GaoJau-Shyong Hong
Dec 24, 2014·Journal of Cellular Physiology·Hany E S MareiCarlo Cenciarelli
Jan 16, 2013·Trends in Molecular Medicine·Yvonne M NolanAndré Toulouse
Aug 19, 2009·Progress in Neurobiology·Caitríona M Long-SmithYvonne M Nolan
Mar 8, 2008·Neurobiology of Aging·Diego MastroeniJoseph Rogers
May 23, 2006·Brain Research·Elias Matthew QuinteroAnn-Charlotte Granholm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.