Dec 5, 1998

Microgliosis and down-regulation of adenosine transporter induced by methamphetamine in rats

Brain Research
Elena EscubedoJ Camarasa

Abstract

Chronic administration of methamphetamine to rats induces neurotoxicity characterized by a loss of striatal dopaminergic terminals and reactive gliosis. Subcutaneous administration of methamphetamine in a scheduled procedure of four doses (10 mg/kg) at 2 h interval also induces a significant increase in the peripheral-type benzodiazepine receptor (PBR) density. This increase is maximum (76%) at 72 h post-treatment in the striatum and disappears at 7 days, suggesting that microglia may have a predominant role in necrosis-phagocytosis of neuronal debris rather than acting in a restorative manner. Microgliosis is not restricted to the striatum since it is also evident in cerebellum (75.4% of PBR increase) and hippocampus (37.2% of PBR increase). In the areas with high density of adenosine transporter, the microgliosis phenomenon correlates well with a decrease of this nucleoside transporter (about 39%). Although the microgliosis and the decrease in adenosine transporter could be parallel and not related events, we can speculate that when microglia are activated, a down-regulation of adenosine transporter occurs, playing a role in tissue homeostasis. With the same dosing schedule, methamphetamine induces HSP72 expression in both cy...Continue Reading

Mentioned in this Paper

Heat shock proteins
Necrosis
Neostriatum
HSPA1A wt Allele
Degenerative Diseases, Spinal Cord
Lentiform Nucleus Structure
Receptor Down-Regulation
Methamphetamine Measurement
Microgliosis
Tissue Homeostasis

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Haruhiko Akiyama
The Journal of Pharmacology and Experimental Therapeutics
M P GygiG R Hanson
© 2020 Meta ULC. All rights reserved