Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal

Brain Research
S RassnickG F Koob

Abstract

Previous studies have shown that spontaneous exploration of the Elevated Plus Maze provides a sensitive measure of 'anxiety' induced by pharmacological or behavioral stressors. In particular, the percent time spent exploring the open arms of the plus maze is decreased during ethanol withdrawal, and this effect is antagonized by intracerebroventricular administration of 25 micrograms of alpha-helical CRF, a corticotropin-releasing factor antagonist (H.A. Baldwin et al., Psychopharmacology, 103 (1991) 227-232). The present study was designed to examine the effect of alpha-helical CRF infusion within the central nucleus of the amygdala during ethanol withdrawal. Rats were made dependent on ethanol by maintenance on an ethanol-containing liquid diet for 16 days, withdrawn from ethanol and tested on the elevated plus maze at 8 h post-ethanol access. In comparison with pair-fed control rats, ethanol withdrawn subjects spent significantly less percent time exploring the open arms of the plus maze. This decrease in open arm exploration was antagonized by administration of alpha-helical CRF (250 ng) bilaterally into the central nucleus of the amygdala, but not by intracerebroventricular administration of 250 ng of alpha-helical CRF. The...Continue Reading

References

Mar 1, 1976·Pharmacology, Biochemistry, and Behavior·L A PohoreckyS L Jaffe
May 1, 1979·Drug and Alcohol Dependence·L VolicerR Meichner
Jan 1, 1991·Psychopharmacology·H A BaldwinK T Britton
Nov 1, 1990·Neuroendocrinology·R L Spencer, B S McEwen
Dec 1, 1987·Annals of Internal Medicine·M LinnoilaB Adinoff
May 1, 1986·Endocrinology·M A SmithC B Nemeroff
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Dec 1, 1983·Neuropharmacology·H Lal, M W Emmett-Oglesby
Apr 23, 1984·Brain Research·L P Gonzalez, M K Hettinger
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·S T Ahlers, M K Salander

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Citations

Oct 1, 1994·Cellular and Molecular Neurobiology·C MöllerM Heilig
Apr 28, 2004·Neurotoxicity Research·F Weiss, G F Koob
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Sachin MoonatSubhash C Pandey
Mar 15, 2005·Psychopharmacology·George R BreeseDarin J Knapp
Oct 30, 2007·Psychopharmacology·Sheila E SpecioGeorge F Koob
Dec 17, 2009·Psychopharmacology·Andrea CippitelliMarkus Heilig
Aug 3, 2010·Psychopharmacology·Nicholas W Gilpin, George F Koob
Jul 10, 2013·Psychopharmacology·Ashlee Van't Veer, William A Carlezon
May 1, 1996·Pharmacology, Biochemistry, and Behavior·S E File
Feb 1, 1994·Trends in Neurosciences·M HeiligK T Britton
Nov 5, 2005·Brain Research. Brain Research Reviews·Adrie W Bruijnzeel, Mark S Gold
Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·George F Koob
Jun 12, 2013·Neuropharmacology·George F KoobOlivier George
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·David H OverstreetGeorge R Breese
Nov 26, 2002·Brain Research·Irina V Zhdanova, Marco Giorgetti
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·P J Kenny, A Markou
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Craig J SlaweckiCindy L Ehlers
Jul 25, 1998·Pharmacology, Biochemistry, and Behavior·G SchulteisG F Koob
Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·C L EhlersT K Li
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Ph De WitteP Verbanck
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·J Menard, D Treit
Aug 26, 1998·Drug and Alcohol Dependence·M J Kreek, G F Koob
Jan 13, 2010·Psychological Review·Barbara L GanzelElaine Wethington
Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Catherine A MarcinkiewczAdrie W Bruijnzeel
Jun 20, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennie R StevensonClyde W Hodge

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