Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever

The American Journal of Physiology
T E ScammellC B Saper

Abstract

Considerable evidence supports the role of prostaglandins in fever production, but the neuroanatomic sites of prostaglandin synthesis that produce fever remain unknown. With the use of a novel microinjection technique, we injected the cyclooxygenase inhibitor ketorolac into the preoptic area (POA) to determine which preoptic regions produce the prostaglandins required for fever. Initial experiments demonstrated that intravenous ketorolac blocked the fever normally produced by lipopolysaccharide (LPS) 5 micrograms/kg i.v. Microinjection of ketorolac into the POA had no effect on body temperature, and injection of artificial cerebrospinal fluid into the POA did not alter LPS fever. Injection of ketorolac into the anteroventral POA markedly decreased the fever produced by LPS, compared with injections into more rostral, caudal, or dorsal locations. These observations indicate that prostaglandin synthesis in the anteroventral preoptic region is necessary for the production of fever.

References

Jan 1, 1979·Canadian Journal of Physiology and Pharmacology·L K VaughnK E Cooper
Sep 1, 1991·Physiology & Behavior·N C LongN Murakami
Jan 1, 1991·Physiological Reviews·M J Kluger
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J A Yergey, M P Heyes
Mar 1, 1988·The Journal of Physiology·A MorimotoT Watanabe
Feb 1, 1988·American Journal of Surgery·R RoscherH G Beger
Sep 1, 1983·Journal of Neuroscience Methods·D G Amaral, J L Price
Oct 1, 1981·The Journal of Experimental Medicine·R C SkarnesJ A McCracken
May 1, 1995·The Journal of Comparative Neurology·C D BrederR P Kraig
Nov 1, 1994·British Journal of Anaesthesia·J E Larsson, G Wahlström
Oct 21, 1996·The Journal of Comparative Neurology·J K Elmquist, C B Saper
Mar 31, 1997·The Journal of Comparative Neurology·F Fernández-de-Miguel

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Citations

Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrei I IvanovAndrej A Romanovsky
Oct 18, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J Madden, S F Morrison
Jun 25, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mutsumi Tanaka, Robin M McAllen
Apr 7, 2009·The Journal of Veterinary Medical Science·Seiji MiyazawaYasutake Shimizu
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kazuhiro Nakamura
Mar 18, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Valter DantonioKênia C Bícego
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J PrendergastRandy J Nelson
Nov 13, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aline S C FabricioGloria E P Souza
Apr 26, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrej A RomanovskyWilliam S Hunter
May 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wataru InoueGiamal N Luheshi
Oct 18, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mutsumi TanakaRobin M McAllen
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M K HansenL R Watkins
Jul 23, 2002·Journal of Applied Physiology·K C BicegoL G S Branco
Oct 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrei I IvanovAndrej A Romanovsky
Jul 1, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christoph RummelGiamal N Luheshi
Jan 9, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J Madden, S F Morrison
Feb 24, 2012·Journal of Neurophysiology·J M HawrylukE Arrigoni
Jan 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sipra SahaAnders Blomqvist
Mar 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toshimasa Osaka
Aug 12, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Douglas G Whyte, Alan Kim Johnson

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