PMID: 11932071Apr 5, 2002Paper

Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity

Pain
S McGaraughty, M M Heinricher

Abstract

The goal of the present study was to identify nuclei of the amygdala in which opioid-sensitive systems can act to recruit nociceptive modulatory circuitry in the rostral ventromedial medulla (RVM) and affect nociceptive responsiveness. In lightly anesthetized rats, 10 microg of morphine was bilaterally microinjected into basolateral, cortical, medial, central, and lateral nuclei of the amygdala to determine the relative influence on the activity of identified ON, OFF and NEUTRAL cells in the RVM and on the latency of the tail flick reflex evoked by noxious radiant heat. Infusions of morphine into the basolateral nuclei resulted in a substantial, naloxone-reversible increase in tail flick latency, and significantly increased ongoing firing of OFF cells and depressed that of ON cells. The reflex-related changes in cell firing were also attenuated. Morphine infusions into the cortical nuclei resulted in a small (approximately 1 s) but significant increase in tail flick latency. As with basolateral microinjections, ongoing activity of the OFF cells was increased, and although the ongoing firing of ON cells was not significantly changed, the reflex-related burst that characterizes these neurons was reduced. Microinjections in the me...Continue Reading

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Vishvarani WanigasekeraIrene Tracey
Jun 4, 2011·Journal of Signal Transduction·Hiroki ImbeYoshiki Kaneoke
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guangchen JiVolker Neugebauer
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ilkka K MartikainenJon-Kar Zubieta
Apr 8, 2015·European Journal of Pain : EJP·J J MaireN R Selden
Jan 17, 2009·Brain Research Reviews·M M HeinricherB M Lumb
Jan 24, 2009·Brain Research Reviews·Volker NeugebauerSean C Mackey
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Feb 6, 2014·The European Journal of Neuroscience·Enza PalazzoSabatino Maione
Dec 19, 2007·The Journal of Comparative Neurology·Jean-François PoulinGuy Drolet
Jan 1, 2013·Journal of Molecular Psychiatry·Pierre VeinanteMichel Barrot
Feb 24, 2009·Pain·Melissa E MartensonMary M Heinricher
Sep 23, 2016·Pain·Zachary RoederMary M Heinricher
Mar 5, 2019·Current Rheumatology Reports·QiLiang Chen, Mary M Heinricher
Oct 28, 2019·British Journal of Pharmacology·Miriam Martínez-NavarroRafael Maldonado

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