Microinjection of the melanin-concentrating hormone into the lateral basal forebrain increases REM sleep and reduces wakefulness in the rat

Life Sciences
Patricia LagosPablo Torterolo

Abstract

To examine the effects of bilateral microinjection of melanin-concentrating hormone (MCH) 50 and 100 ng into the horizontal limb of the diagonal band of Broca (HDB) on sleep variables during the light phase of the light-dark cycle of the rat. Male Wistar rats were implanted for chronic sleep recordings. In addition, a guide cannula was implanted above the right and left HDB. Following the microinjection of MCH or control solution the electroencephalogram and the electromyogram were recorded for 6 h. Data was collected and classified as either wakefulness (W), light sleep, slow wave sleep (SWS) or REM sleep (REMS). Latencies for SWS and REMS, as well as the number of REM periods and the mean duration of REM episodes were also determined. MCH 50 and 100 ng significantly decreased W during the first 2-h of recording. Moreover, MCH 100 ng significantly reduced REMS latency and increased REMS time during the first 2-h block of the recording, due to an increase in the number of REM periods. Our findings tend to suggest that the basal forebrain participates in the effects of MCH on W and REMS through the deactivation of cholinergic, glutamatergic and γ-aminobutyric acid (GABA)-ergic cells.

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Citations

Mar 13, 2013·Sleep Medicine Reviews·Jaime M MontiPatricia Lagos
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roda Rani KonadhodePriyattam J Shiromani
Dec 3, 2013·Sleep·Pierre-Hervé LuppiPatrice Fort
Dec 3, 2013·Sleep·Sonia Jego, Antoine Adamantidis
Dec 15, 2015·Chronobiology International·Chul-Hyun ChoEun-Il Lee
Mar 19, 2014·The Journal of Physiology·Gregory S ParksXiangmin Xu
Jan 7, 2016·Frontiers in Neuroscience·Pablo TorteroloJaime M Monti
Dec 30, 2014·Brain Research·Andrea DeveraPablo Torterolo
Oct 18, 2014·Frontiers in Systems Neuroscience·Sandrine ChomettonPierre-Yves Risold
Oct 3, 2020·Current Neurology and Neuroscience Reports·Sathyajit S BandaruRamalingam Vetrivelan
Jun 15, 2017·Frontiers in Systems Neuroscience·Giovanne B Diniz, Jackson C Bittencourt

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