PMID: 9554999May 21, 1998Paper

Microinjections of anisomycin into the intermediate cerebellum during learning affect the acquisition of classically conditioned responses in the rabbit

Brain Research
V BrachaJ R Bloedel

Abstract

The purpose of this study was to examine the effects of protein synthesis inhibition in the intermediate cerebellum on the acquisition and expression of classically conditioned nictitating membrane responses in the rabbit. Animals were conditioned for three days in a standard delay paradigm. Before each training session, either a solution of anisomycin (a protein synthesis inhibitor) or vehicle was bilaterally injected into the interposed cerebellar nuclear. Following these three training sessions, rabbits were tested to determine whether the previous training under the influence of anisomycin or vehicle resulted in the acquisition of conditioned responses. In this test, animals that were injected previously with the protein synthesis inhibitor exhibited significantly less retention of conditioned responses than rabbits injected with vehicle. Additional experiments demonstrated that anisomycin does not block the expression of conditioned responses during conditioning or in well-trained animals. Microinjections of muscimol at the same sites of the previous drug infusions suppressed the expression of conditioned responses, indicating that the protein synthesis inhibitor was applied to the eyeblink-related parts of cerebellar circ...Continue Reading

Citations

Sep 5, 2003·Genes, Brain, and Behavior·V D'AgataS Cavallaro
Feb 16, 2005·Annual Review of Psychology·Richard F Thompson
Oct 31, 2012·The European Journal of Neuroscience·Jonathan J SzalayKathleen M Kantak
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey A KleimDrew Walters
Mar 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jin-Sung ParkShigeyoshi Itohara
Jan 12, 2011·Neurochemical Research·Kyoichi EmiMichisuke Yuzaki
Mar 13, 2015·Frontiers in Computational Neuroscience·Claudia CasellatoAlessandra Pedrocchi
Feb 16, 2005·Annual Review of Psychology·Michael S Fanselow, Andrew M Poulos
Dec 6, 2003·Learning & Memory·Kimberly M Christian, Richard F Thompson
Oct 5, 2011·Learning & Memory·John H Freeman, Adam B Steinmetz
Sep 22, 2011·Behavioural Brain Research·Andrew J CarrelVlastislav Bracha

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