PMID: 8986012Dec 1, 1996Paper

Microinjections of phencyclidine (PCP) and related drugs into nucleus accumbens shell potentiate medial forebrain bundle brain stimulation reward

Psychopharmacology
William A Carlezon, R A Wise

Abstract

Microinjections of phencyclidine (PCP) into the ventro-medial portion of nucleus accumbens in rats potentiated the rewarding impact of lateral hypothalamic brain stimulation. Similar effects were found with nomifensine, which shares with PCP the ability to block dopamine uptake and thus elevate synaptic dopamine levels but does not share with PCP the ability to block NMDA receptors. Similar effects were also seen with dizocilpine (MK-801) and [3-((+/-)2-carboxypiperazin-4-yl)propyl-1-phosphonate] (CPP), which share with PCP the ability to block NMDA receptors but not to block dopamine uptake. Thus PCP's properties as a dopamine uptake inhibitor and as an NMDA receptor antagonist each appear capable of producing reward-related actions in this brain region. The common denominator of these two PCP actions is decreased output of medium spiny neurons; these neurons are tonically activated by a glutamate projection from prefrontal cortex (PCP blocks this source of activation) and are tonically inhibited by a dopaminergic projection from the ventral tegmental area (PCP augments this inhibition).

Citations

Nov 20, 2003·Neuroscience and Biobehavioral Reviews·Davide ViggianoAdolfo G Sadile
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Sarah M Turgeon, Stephen G Hoge
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Eliot L Gardner
Mar 10, 2000·European Journal of Pharmacology·A Y BespalovR L Balster
May 19, 1998·Trends in Pharmacological Sciences·L J VanderschurenT J De Vries
Jun 16, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·C A HeidbrederJ Feldon
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Apr 1, 1996·Current Opinion in Neurobiology·R A Wise
Sep 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bin WangRoy A Wise
Nov 17, 2007·Nature Protocols·William A Carlezon, Elena H Chartoff
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
Aug 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zheng-Xiong XiEliot L Gardner
Apr 29, 1998·Neuroreport·T J De VriesL J Vanderschuren
Jul 23, 1999·Annals of the New York Academy of Sciences·D S Zahm
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael KrauseHoward L Fields
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nobuyoshi Suto, Roy A Wise
Jan 10, 2009·European Journal of Pharmacology·Gail Pereira Do CarmoS Stevens Negus
May 19, 2007·European Journal of Pharmacology·Mohammad-Reza ZarrindastFarzaneh Nazari-Serenjeh
Jun 13, 2003·Life Sciences·Ralph J DiLeoneEric J Nestler
Aug 18, 2004·British Journal of Pharmacology·Carl R LupicaAlexander F Hoffman
Sep 29, 2009·Brain Research·Allison T Knoll, William A Carlezon
Sep 2, 2006·Biological Psychiatry·Fumihiko YasunoTetsuya Suhara
Apr 13, 2011·Biological Psychiatry·Robert A WheelerRegina M Carelli
Jan 15, 2015·Pharmacology & Therapeutics·William T O'Connor, Sean D O'Shea

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.