PMID: 9190972Jun 1, 1997Paper

Microinvasive carcinoma of the uterine cervix: histological findings on cone specimens related to residual neoplasia on hysterectomy

Gynecologic Oncology
M S GurgelK Panetta

Abstract

The treatment of cervical microinvasive carcinoma is controversial. Hysterectomy is performed in almost all cases, associated or not with more radical procedures. Currently, there is a tendency to adopt conservative management to treat patients with early invasion, as long as it can be assured that the whole lesion has been removed. The aim of this study was to establish which histological information should be obtained from the cones that would give the best possible assurance of absence of residual neoplasia in the patient. This was done by comparing cone and hysterectomy specimens from each patient. One hundred sixty-three cases, treated from 1967 to 1994, underwent simple or radical hysterectomy following cone biopsy. We evaluated the following histological features in the cones: (i) invasion depth, (ii) lateral extension of the lesion, (iii) unifocal or extensive lesion, (iv) vascular invasion, (v) morphological signs of HPV infection, and (vi) free or involved cone surgical margins. Residual neoplasia in the hysterectomy was more frequent when the margins of the cone were involved by atypical epithelium, and in cases with signs of HPV infection. However, according to statistical analysis, these two variables were not mutu...Continue Reading

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Aug 1, 1992·Gynecologic Oncology·S Paterson-BrownK S Raju
Jun 1, 1992·Gynecologic Oncology·L J CopelandJ T Wharton
Sep 15, 1985·American Journal of Obstetrics and Gynecology·W T CreasmanR T Parker
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Jul 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A G Ostör

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Citations

Oct 9, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R L M BekkersL F A G Massuger
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C PhongnarisornT Pantasri
Jan 26, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Woo Young KimHee-Sug Ryu
Aug 23, 2011·American Journal of Obstetrics and Gynecology·Yara FurtadoPaula Maldonado
Dec 17, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Caio Augusto HartmanJoana Froes Bragança Bastos
Mar 6, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Juliana Yoko YonedaLuiz Carlos Zeferino
May 2, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Sun-Joo LeeDuk-Soo Bae
Dec 4, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Teresa M DarraghUNKNOWN Members of the LAST Project Work Groups
Aug 12, 2014·Advances in Anatomic Pathology·Kruti P Maniar, Ritu Nayar
Jul 27, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Julia Elizabeth PalmerJohn A Tidy

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