Microiontophoretic application of serotonin (5HT)1B/1D agonists inhibits trigeminal cell firing in the cat

Brain : a Journal of Neurology
R J Storer, Peter J Goadsby

Abstract

Migraine is a common and debilitating condition. Its treatment has received considerable attention in recent times with the introduction into clinical use of the 5HT1B/1D agonist sumatriptan. It is known from human studies that the intracranial blood vessels and dura mater are important pain-producing structures since mechanical or electrical stimulation of these vessels, such as the superior sagittal sinus, causes pain. We have developed a model of craniovascular pain by stimulating the superior sagittal sinus and monitoring trigeminal neuronal activity using electrophysiological techniques. Cats were anaesthetized with alpha-chloralose (60 mg/kg, intraperitoneally), paralysed (gallamine 6 mg/kg, intravenously) and ventilated. The superior sagittal sinus was accessed and isolated for electrical stimulation by a mid-line circular craniotomy. The region of the dorsal surface of C2 spinal cord was exposed by a laminectomy and an electrode placed for recording evoked activity from sinus stimulation and spontaneous activity of the same cells. The electrode was a custom-made seven barrel glass microelectrode with the central barrel containing a tungsten recording wire. Signals were amplified and monitored on-line using a custom-writ...Continue Reading

Citations

Mar 17, 2009·Experimental Brain Research·Karl Messlinger
Mar 14, 2001·Brain Research. Brain Research Reviews·D D Mitsikostas, M Sanchez del Rio
Jun 28, 2000·Progress in Neurobiology·P J Goadsby
Mar 12, 2004·The New England Journal of Medicine·Jes OlesenUNKNOWN BIBN 4096 BS Clinical Proof of Concept Study Group
May 25, 2004·Cephalalgia : an International Journal of Headache·A OterinoJ Pascual
Nov 30, 2004·Cephalalgia : an International Journal of Headache·R J Storer, P J Goadsby
Jun 30, 2007·Cephalalgia : an International Journal of Headache·L M Cupini, E Stipa
Aug 24, 2007·Cephalalgia : an International Journal of Headache·E RubinoL Pinessi
Aug 30, 2008·Cephalalgia : an International Journal of Headache·L Edvinsson, P Tfelt-Hansen
Jun 6, 2009·Cephalalgia : an International Journal of Headache·E A BatesA H Ahn
May 28, 2005·European Neurology·Peter J Goadsby
Jul 29, 2010·BMC Research Notes·Annie LiuLyn R Griffiths
Nov 24, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·E Hamel
Apr 8, 2006·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Erling TronvikGunnar Bovim
May 23, 2001·The Journal of Comparative Neurology·L M Hurley, A M Thompson
Mar 2, 2010·Expert Review of Neurotherapeutics·Anna P AndreouPeter J Goadsby
May 7, 2008·Expert Review of Neurotherapeutics·Arthur H Elkind, E Anne MacGregor
Aug 21, 2013·Expert Review of Neurotherapeutics·Simon Akerman, Marcela Romero-Reyes
Aug 22, 2013·Expert Opinion on Drug Discovery·Sieneke LabruijereAntoinette Maassenvandenbrink
Jan 5, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Robert L Ruff
Aug 30, 2011·Journal of Neuroscience Methods·Shannon B OlssonBill S Hansson
Oct 20, 2009·Neurobiology of Disease·Anna P AndreouPeter J Goadsby
Mar 18, 2009·Neurologic Clinics·Peter J Goadsby
Dec 5, 2006·Trends in Molecular Medicine·Peter J Goadsby
Jul 9, 2004·British Journal of Pharmacology·Robin James StorerPeter J Goadsby
Jan 4, 2006·CNS Drug Reviews·Geoffrey A Lambert
Jun 28, 2005·British Journal of Pharmacology·Simon Akerman, Peter J Goadsby

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