Micromachined lab-on-a-tube sensors for simultaneous brain temperature and cerebral blood flow measurements

Biomedical Microdevices
Chunyan LiRaj K Narayan

Abstract

This work describes the development of a micromachined lab-on-a-tube device for simultaneous measurement of brain temperature and regional cerebral blood flow. The device consists of two micromachined gold resistance temperature detectors with a 4-wire configuration. One is used as a temperature sensor and the other as a flow sensor. The temperature sensor operates with AC excitation current of 500 μA and updates its outputs at a rate of 5 Hz. The flow sensor employs a periodic heating and cooling technique under constant-temperature mode and updates its outputs at a rate of 0.1 Hz. The temperature sensor is also used to compensate for temperature changes during the heating period of the flow sensor to improve the accuracy of flow measurements. To prevent thermal and electronic crosstalk between the sensors, the temperature sensor is located outside the "thermal influence" region of the flow sensor and the sensors are separated into two different layers with a thin-film Copper shield. We evaluated the sensors for accuracy, crosstalk and long-term drift in human blood-stained cerebrospinal fluid. These in vitro experiments showed that simultaneous temperature and flow measurements with a single lab-on-a-tube device are accurate ...Continue Reading

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Citations

Jan 19, 2016·Biomedical Microdevices·Chunyan LiJed A Hartings
Sep 12, 2014·Neurocritical Care·Paul VespaUNKNOWN Participants in the International Multi-disciplinary Consensus Conference on Multimodality Monitoring
Sep 7, 2016·Frontiers in Neuroscience·Kanokwan LimnusonChunyan Li
Sep 2, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chunyan LiJed A Hartings
Nov 15, 2018·Micromachines·S Beatriz GoncalvesJosé H Correia

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