Micromanaging of tumor metastasis by extracellular vesicles

Seminars in Cell & Developmental Biology
Naoomi TominagaTakahiro Ochiya

Abstract

Extracellular vesicles (EVs) are nanometer-sized membranous vesicles that are released by a variety of cell types into the extracellular space. In the past two decades, EVs have emerged as novel mediators of cancer biology. Many reports have demonstrated the contribution of EVs to cancer metastasis. Metastasis is a multistep process that is responsible for the majority of deaths in cancer patients. This process includes proliferation, angiogenesis, immune modulation, extravasation, intravasation, and colonization. EVs from cancer cells impact these steps through modulation of the host immune system, angiogenesis, and pre-/pro-metastatic niche formation. In this review, we summarize the function of EVs in cancer metastasis. In addition, we also discuss the hurdles to be overcome for further developing this research field.

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Citations

Oct 21, 2015·Advanced Drug Delivery Reviews·Naoomi TominagaTakahiro Ochiya
Jan 23, 2016·Cancer Science·Yu FujitaTakahiro Ochiya
Feb 27, 2019·MicroRNA·Jéssica Zani LacerdaDebora Aparecida Pires de Campos Zuccari
Jan 8, 2020·Cancers·Carla Solé, Charles H Lawrie
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Naoya KuriyamaTakahiro Ochiya
Jul 22, 2021·International Journal of Nanomedicine·Jin WenGuorong Li

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