Micromechanical analysis of brain's diffuse axonal injury

Journal of Biomechanics
Amir Mohammadipour, Alireza Alemi

Abstract

Computational models are important tools which help researchers understand traumatic brain injury (TBI). A mechanistic multi-scale numerical approach is introduced to quantify diffuse axonal injury (DAI), the most important mechanism of TBI, induced by a mechanical insult at micro-scale regions of the white matter or voxels where fiber orientations are the same. Using the mechanical properties of a single axon with a viscoelastic constitutive relation and its functional failure in terms of electrophysiological impairment, a numerical 2D micro-level lattice method is implemented to directly analyze the percentage of injured axons in a voxel containing a bundle of axons all with the same orientation under biaxial stretches. Reference micro-injury maps are then developed with the input parameters based on the principal strain or stretch values and their direction with respect to axons, which provide the percentage of injured axons in the voxel of interest as the output. The methodology is independent of any statistical analyses of the accident data and medical reports to derive probabilistic injury risk curves for DAI. Avoiding a structurally detailed full finite element head model, this study proposes a micro-mechanical approach ...Continue Reading

Citations

Feb 1, 2020·Reviews in the Neurosciences·Haym Benaroya
Nov 16, 2018·Biomechanics and Modeling in Mechanobiology·Ilaria CinelliMaeve Duffy
Nov 25, 2019·Biomechanics and Modeling in Mechanobiology·Shaoju WuSongbai Ji
Sep 27, 2019·Journal of Biomechanical Engineering·Annaclaudia MontaninoSvein Kleiven

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.