Micromechanical and physical stability analysis of an irradiated poly (lactic-co-glycolic acid) donut-shaped minitablet device for intraocular implantation

Pharmaceutical Development and Technology
Yahya E ChoonaraRiaz A Khan

Abstract

This study pragmatically characterized the micromechanical and physical stability of a poly(lactic-co-glycolic acid) (PLGA)-based ganciclovir (GCV)-loaded donut-shaped minitablet (DSMT) device for intraocular implantation. Thermal and spectroscopic analysis was performed on various drug-polymer permutations. Porositometric profiles were quantitatively analyzed coupled with qualitatively SEM imaging. The tensile strength (TS) and fracture energy (FE) of the device was also determined pre- and post-γ-sterilization. Inimitably, chemometric and molecular modeling provided a supportive confirmatory tool for establishing fundamental correlative suppositions between the transitioned surface morphology and the micromechanical stability after γ-irradiation. Isotherm plot volumes ranged between -0.028 ± 0.022 and 0.110 ± 0.005 m(2)/g for pre- and post-sterilized devices, respectively, revealing a microporous alteration in porosity. Pre-sterilized devices had larger pores (BJHa=286.22 vs. 192.49 Å) and lower FE (151.301 ± 6.089 N/m) and TS (26.396 ± 1.062 N) values while sterilized devices had crystalline matrices that facilitated the superiorly controlled drug release kinetcs obtained. DSC thermograms displayed the characteristic disorde...Continue Reading

References

Apr 1, 1977·The Journal of Pharmacy and Pharmacology·E Doelker, E Shotton
Apr 1, 1977·Journal of Pharmaceutical Sciences·E N HiestandJ F Ochs
Jul 1, 1975·Journal of Pharmaceutical Sciences·E Shotton, B A Obiorah
May 1, 1970·Journal of Pharmaceutical Sciences·J T Fell, J M Newton
Nov 5, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·L MontanariI Genta
Apr 1, 1999·Pharmaceutical Research·A ShenderovaS P Schwendeman
Sep 2, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·D MohrT Kissel
Jun 6, 2000·Advanced Drug Delivery Reviews·M S Shive, J M Anderson
Mar 7, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Z NaimaD Jerome
Aug 15, 2002·International Journal of Pharmaceutics·N FaisantJ Benoit
Nov 7, 2003·International Journal of Pharmaceutics·Kazunari YamashitaToshikiro Kimura
Sep 1, 2004·International Journal of Pharmaceutics·Anshuman A AmbikeAnant Paradkar
Jan 3, 2006·Pharmaceutical Research·Sergey Vyazovkin, Ion Dranca
Feb 8, 2006·International Journal of Pharmaceutics·Yahya E ChoonaraMichael P Danckwerts
Jul 21, 2006·The Journal of Physical Chemistry. B·Sergey Vyazovkin, Ion Dranca

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