Micromechanical characterization of intra-luminal thrombus tissue from abdominal aortic aneurysms

Annals of Biomedical Engineering
T Christian GasserJ Swedenborg

Abstract

The reliable assessment of Abdominal Aortic Aneurysm rupture risk is critically important in reducing related mortality without unnecessarily increasing the rate of elective repair. Intra-luminal thrombus (ILT) has multiple biomechanical and biochemical impacts on the underlying aneurysm wall and thrombus failure might be linked to aneurysm rupture. Histological slices from 7 ILTs were analyzed using a sequence of automatic image processing and feature analyzing steps. Derived microstructural data was used to define Representative Volume Elements (RVE), which in turn allowed the estimation of microscopic material properties using the non-linear Finite Element Method. ILT tissue exhibited complex microstructural arrangement with larger pores in the abluminal layer than in the luminal layer. The microstructure was isotropic in the abluminal layer, whereas pores started to orient along the circumferential direction towards the luminal site. ILT's macroscopic (reversible) deformability was supported by large pores in the microstructure and the inhomogeneous structure explains in part the radially changing macroscopic constitutive properties of ILT. Its microscopic properties decreased just slightly from the luminal to the abluminal...Continue Reading

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Citations

Mar 6, 2013·Cardiovascular Research·Magnus BäckGiuseppina Caligiuri
Mar 1, 2013·Journal of Biomechanical Engineering·Giampaolo Martufi, T Christian Gasser
Aug 31, 2012·Biomedical Engineering Online·Stanislav PolzerPavel Skacel
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Balakrishnan SivaramanAnand Ramamurthi
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Dec 31, 2014·Medical & Biological Engineering & Computing·Eleni MetaxaYannis Papaharilaou
Apr 12, 2011·Medical Engineering & Physics·Florentina EneLiam Morris
Jul 14, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Carsten Behr AndersenHans Christian Beck
Dec 3, 2010·Current Opinion in Rheumatology

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