Micromechanical oscillators as rapid biosensor for the detection of active growth of Escherichia coli

Biosensors & Bioelectronics
Karin Y GfellerM Hegner


A rapid biosensor for the detection of bacterial growth was developed using micromechanical oscillators coated by common nutritive layers. The change in resonance frequency as a function of the increasing mass on a cantilever array forms the basis of the detection scheme. The sensor is able to detect active growth of Escherichia coli cells within 1 h which is significantly faster than any conventional plating method which requires at least 24 h. The growth of E. coli was confirmed by scanning electron microscopy. This new sensing method for the detection of active bacterial growth allows future applications in, e.g., rapid antibiotic susceptibility testing by adding antibiotics to the nutritive layer.


Mar 31, 2000·Ultramicroscopy·A M MoulinM E Welland
Apr 15, 2000·Science·J FritzJ K Gimzewski
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rachel A McKendryChristoph Gerber
Oct 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·W LiuVladimir Parpura
Feb 27, 2004·International Journal of Food Microbiology·Florent Baty, Marie-Laure Delignette-Muller


Mar 18, 2006·Analytical and Bioanalytical Chemistry·Ralf Lucklum, Peter Hauptmann
May 26, 2005·Biosensors & Bioelectronics·David MaraldoRaj Mutharasan
Jan 9, 2010·Analytical Chemistry·Chia Hsiang ChenPak Kin Wong
Jan 24, 2013·Environmental Science & Technology·Kamila CzechowskaJan Roelof van der Meer
Dec 6, 2011·Nano Letters·Andreas MaderMadeleine Leisner
Mar 29, 2011·Nature Nanotechnology·J L ArlettM L Roukes
Jul 4, 2013·Nature Nanotechnology·Rachel A McKendry, Natascha Kappeler
Nov 1, 2011·Lab on a Chip·Jungwook ParkHiroyuki Fujita
Sep 26, 2006·Applied and Environmental Microbiology·L SilbertR Jelinek
Mar 15, 2013·Journal of Clinical Microbiology·Alex van Belkum, W Michael Dunne
Jul 20, 2010·Annual Review of Analytical Chemistry·Kyo Seon HwangTae Song Kim
Feb 13, 2014·The Review of Scientific Instruments·N MaloneyM Hegner
Oct 16, 2014·Applied Physics Letters·C LissandrelloKamil L Ekinci
Mar 27, 2010·Analytical Chemistry·Scott M KnudsenS R Manalis
Sep 8, 2010·Journal of Photochemistry and Photobiology. B, Biology·Mohammad Ismail ZibaiiMohammad Hossein Ghezelaiagh
Jan 13, 2009·Trends in Biotechnology·Nesli Sozer, Jozef L Kokini
Nov 2, 2007·Journal of Applied Microbiology·D MeirR Jelinek
Jul 24, 2012·Biochemical Society Transactions·Rachel A McKendry
Oct 10, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Carla M DuarteRicardo Bexiga
Sep 6, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A SchumacherP Habibovic
Jul 2, 2016·Essays in Biochemistry·Ronen FogelAshwin A Seshia
Oct 12, 2012·Applied Microbiology and Biotechnology·Varnika RoyWilliam E Bentley
Sep 16, 2017·Journal of Food and Drug Analysis·Kavitha PathakotiHuey-Min Hwang
Dec 25, 2010·Lab on a Chip·J LeeS R Manalis
Feb 27, 2020·Scientific Reports·Masoud SoltanRezaee, Mahdi Bodaghi

Related Concepts

Real-Time Systems
Medical Device Design
Alkalescens-Dispar Group
Streak Plate Count
Biosensing Techniques
Prosthesis Failure Analysis
Cell Proliferation

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Natalia NugaevaM Hegner
© 2021 Meta ULC. All rights reserved