Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes

Science
M BaudryG S Lynch

Abstract

Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.

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Citations

Aug 11, 1981·Molecular and Cellular Biochemistry·M Baudry, G Lynch
Mar 1, 1984·Neurochemical Research·A P Larder, H McLennan
Apr 1, 1991·Neurochemical Research·E Arrigoni, F Cohadon
Oct 7, 2010·Molecular Neurobiology·Sohila ZadranMichel Baudry
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Sep 1, 1988·Brain Research Bulletin·G LynchJ Larson
Jan 1, 1993·Brain Research Bulletin·C M BorgheseO A Ramírez

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