Microneedle-mediated minimally invasive patient monitoring

Therapeutic Drug Monitoring
Ryan F DonnellyJames C McElnay

Abstract

The emerging field of microneedle-based minimally invasive patient monitoring and diagnosis is reviewed. Microneedle arrays consist of rows of micron-scale projections attached to a solid support. They have been widely investigated for transdermal drug and vaccine delivery applications since the late 1990s. However, researchers and clinicians have recently realized the great potential of microneedles for extraction of skin interstitial fluid and, less commonly, blood, for enhanced monitoring of patient health. We reviewed the journal and patent literature, and summarized the findings and provided technical insights and critical analysis. We describe the basic concepts in detail and extensively review the work performed to date. It is our view that microneedles will have an important role to play in clinical management of patients and will ultimately improve therapeutic outcomes for people worldwide.

References

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Citations

Oct 18, 2016·Drug Delivery·Karmen Cheung, Diganta B Das
Sep 2, 2018·Analytical and Bioanalytical Chemistry·Sheniqua BrownLeah Tolosa
Jun 15, 2020·Current Environmental Health Reports·Lauren M PetrickMegan M Niedzwiecki
Mar 27, 2015·The International Journal of Pharmacy Practice·Karen MooneyRyan F Donnelly
Nov 27, 2020·Macromolecular Bioscience·Joseph G TurnerHannah S Leese
Jan 22, 2021·Drug Delivery and Translational Research·Delly RamadonRyan F Donnelly
Jan 5, 2019·Advanced Healthcare Materials·Chandana KolluruMark R Prausnitz
Jun 11, 2021·Advanced Drug Delivery Reviews·Emma McAlisterRyan F Donnelly
Nov 5, 2014·Analytical Chemistry·Andrey V RomanyukMark R Prausnitz
Aug 28, 2021·Advanced Healthcare Materials·Li ZhaoRyan F Donnelly
Sep 4, 2015·Bioanalysis·James C McElnay
Apr 5, 2017·Annual Review of Chemical and Biomolecular Engineering·Mark R Prausnitz

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