Microneedles for drug and vaccine delivery.

Advanced Drug Delivery Reviews
Yeu-Chun KimMark R Prausnitz

Abstract

Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990's when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encapsulate drug and fully dissolve in the skin and (iv) hollow microneedles for drug infusion into the skin. As shown in more than 350 papers now published in the field, microneedles have been used to deliver a broad range of different low molecular weight drugs, biotherapeutics and vaccines, including published human studies with a number of small-molecule and protein drugs and vaccines. Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle remova...Continue Reading

References

Dec 1, 1994·IEEE Transactions on Bio-medical Engineering·A C Hoogerwerf, K D Wise
Nov 1, 1994·Chest·P M FlynnB G Williams
Aug 4, 1998·Journal of Pharmaceutical Sciences·S HenryM R Prausnitz
Nov 13, 1998·Journal of Pharmaceutical Sciences·M L ReedM D Feldman
May 1, 1999·Journal of Neuroscience Methods·P J Rousche, R A Normann
Jul 9, 1999·Vision Research·R A NormannD J Warren
Apr 1, 2000·IEEE Transactions on Bio-medical Engineering·Q BaiD J Anderson
Feb 13, 2001·Anesthesia and Analgesia·S KaushikM R Prausnitz
May 1, 2001·IEEE Transactions on Bio-medical Engineering·P J RouscheD R Kipke
Jul 27, 2001·Diabetes Technology & Therapeutics·W H Smart, K Subramanian
Jun 6, 2002·IEEE Transactions on Bio-medical Engineering·Patrick GrissGöran Stemme
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Devin V McAllisterMark R Prausnitz
Mar 17, 2004·Advanced Drug Delivery Reviews·Mark R Prausnitz
Mar 25, 2004·Nature Reviews. Immunology·Thomas S Kupper, Robert C Fuhlbrigge
May 28, 2004·Virus Research·Robert B Belshe
Jun 11, 2004·IEEE Transactions on Bio-medical Engineering·Rio J VetterDaryl R Kipke
Jun 24, 2004·Pharmaceutical Research·Wijaya MartantoMark R Prausnitz
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michel CormierPete Daddona
Sep 21, 2004·Biomedical Microdevices·Ming Yang, Jeffrey D Zahn
Nov 5, 2004·The New England Journal of Medicine·Robert B BelsheGary Dubin
Dec 21, 2004·The Journal of Infectious Diseases·John A MiksztaNoel G Harvey
Mar 2, 2005·Diabetes Technology & Therapeutics·Ping M WangMark R Prausnitz
Mar 3, 2005·Biosensors & Bioelectronics·Sung Woong HanJun Miyake
Apr 6, 2005·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Raja K SivamaniHoward Maibach
Apr 19, 2005·Biomedical Microdevices·Melissa Ai Ling TeoShabbir Moochhala
Apr 19, 2005·Biomedical Microdevices·Jeffrey D ZahnDorian Liepmann
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jung-Hwan ParkMark R Prausnitz
May 13, 2005·IEEE Transactions on Bio-medical Engineering·Shawn P DavisMark R Prausnitz
Jun 1, 2005·Biochemical and Biophysical Research Communications·SungWoong HanJun Miyake
Sep 1, 2005·Biomedical Microdevices·Takaya MiyanoKatsumi Hanada
Oct 22, 2005·Nature Reviews. Immunology·Samir Mitragotri
Nov 26, 2005·Pharmaceutical Research·Wijaya MartantoMark R Prausnitz
Dec 20, 2005·Expert Review of Medical Devices·James C Birchall
Jan 24, 2006·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Selim SunerJohn P Donoghue
Feb 14, 2006·Diabetes Technology & Therapeutics·Hubert W VesperGary L Myers
Feb 18, 2006·The Journal of Investigative Dermatology·Ping M WangMark R Prausnitz
Mar 28, 2006·Advanced Drug Delivery Reviews·Erin L Giudice, James D Campbell
Apr 22, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wijaya MartantoMark R Prausnitz
May 23, 2006·Pharmaceutical Research·Jung-Hwan ParkMark R Prausnitz
Jul 11, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yukako ItoKanji Takada
Jul 18, 2006·Ultrasonics·Lining SunYaxin Liu
Aug 3, 2006·Journal of Drug Targeting·Yukako ItoKanji Takada

❮ Previous
Next ❯

Citations

May 22, 2013·Biotechnology Letters·Atul Nayak, Diganta Bhusan Das
Dec 1, 2012·Pharmaceutical Research·Samantha N AndrewsMark R Prausnitz
Aug 2, 2013·Pharmaceutical Research·Bekir BedizO Burak Ozdoganlar
Oct 1, 2013·Trends in Cell Biology·Sandro Goruppi, G Paolo Dotto
Dec 10, 2013·Nature Biotechnology·Peter C DeMuthDarrell J Irvine
Nov 19, 2013·Viral Immunology·Fu-Shi QuanSang-Moo Kang
Jul 19, 2013·Clinical and Vaccine Immunology : CVI·Fu-Shi QuanSang-Moo Kang
Mar 8, 2012·MBio·Maria del Pilar MartinRichard W Compans
May 9, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunaina IndermunViness Pillay
May 3, 2014·Viruses·Han ZhangBao-Zhong Wang
Apr 25, 2014·The AAPS Journal·Koen van der MaadenJoke Bouwstra
Aug 1, 2013·Advanced Drug Delivery Reviews·Goran T VladisavljevićIsao Kobayashi
Jun 4, 2013·Advanced Drug Delivery Reviews·Nam-Trung NguyenDinh-Tuan Phan
Jul 17, 2013·Advanced Drug Delivery Reviews·Eric Nuxoll
Jan 23, 2014·Pharmaceutical Research·Jaspreet Singh KochharLifeng Kang
Jul 16, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kang Ju LeeWonHyoung Ryu
Aug 26, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Koen van der MaadenJoke Bouwstra
Aug 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xinyuan ChenMei X Wu
Dec 3, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Qingqing WangChuanbin Wu
May 14, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Koen van der MaadenJoke Bouwstra
May 29, 2014·Pharmaceutical Research·Zhuangzhi ZhuHao Wang
Dec 10, 2014·Expert Review of Vaccines·Kate E Broderick, Laurent M Humeau
Jan 2, 2016·International Journal of Pharmaceutics·Evin A AllenAbina M Crean
Nov 13, 2015·Expert Opinion on Drug Delivery·N Sanoj RejinoldYeu-Chun Kim
Jul 16, 2014·Expert Opinion on Drug Delivery·Helen L QuinnRyan F Donnelly
Feb 14, 2014·Expert Opinion on Drug Delivery·Harvinder S GillRichard W Compans
Sep 4, 2014·Drug Delivery·Amit KumarZhengrong Cui
Feb 22, 2013·Expert Opinion on Drug Delivery·Sandra ScheiblhoferRichard Weiss
Jan 16, 2013·Expert Opinion on Drug Delivery·Sachiko HirobeShinsaku Nakagawa
Feb 19, 2016·Scientific Reports·Yan DengTao Tang
Dec 10, 2013·Drug Delivery·Dongwei ZhangChris D Rielly
Apr 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aaron C Anselmo, Samir Mitragotri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Koen van der MaadenJ A Bouwstra
Current Topics in Microbiology and Immunology
Mark R PrausnitzAlexander K Andrianov
Diabetes Technology & Therapeutics
Ahmed El-LaboudiDesmond Johnston
Current Topics in Microbiology and Immunology
Y C KimMark R Prausnitz
© 2021 Meta ULC. All rights reserved