Microneedles for vaccine delivery: challenges and future perspectives

Therapeutic Delivery
Chong In ShinYeu-Chun Kim

Abstract

Vaccine delivery to the skin using conventional needles is associated with needle-stick injuries and needle-phobia, which are all major obstacles to vaccination. The development of microneedles has enabled to overcome these limitations and as a result viral, DNA and bacterial vaccines have been studied for the delivery into the skin. Research has shown the superiority of microneedle vaccination over conventional needles in terms of immunogenicity, vaccine stability and dose-sparing abilities in animals and humans. Additional research on improving vaccine stability and delivering vaccines to other areas of the body besides the skin is ongoing as well. Thus, this review paper describes current advances in microneedles as a delivery system for vaccines as well as future perspectives for this research field.

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Citations

Jan 14, 2018·Scientific Reports·Theresa K ReschBaoming Jiang
Jul 16, 2020·Human Vaccines & Immunotherapeutics·Thuy Trang NguyenJung-Hwan Park
Aug 3, 2019·Pharmaceutics·Chong In ShinYeu-Chun Kim
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Feb 19, 2021·Drug Delivery and Translational Research·Carmine D'AmicoHélder A Santos
Feb 5, 2021·International Journal of Pharmaceutics·Nafiseh ElahpourFilippo Berto

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Methods Mentioned

BETA
irradiates
x-ray lithography

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