PMID: 9184951May 1, 1997Paper

Micronized flavonoid therapy in internal hemorrhoids of pregnancy

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
K BucksheeN Aggarwal

Abstract

To assess the safety, efficacy and acceptability of a micronized flavonoid formulation in the treatment of internal hemorrhoids of pregnancy. In an open study on hospital outpatients, we studied therapy with micronized diosmin 90% and hesperidin 10% for a median of 8 weeks before delivery and 4 weeks after delivery, in 50 women with acute hemorrhoids. The outcome measures were symptoms and signs of hemorrhoids; adverse effects; and acceptability of treatment. On intention to treat analysis, 66% (95% confidence interval, range 79.1-52.9) had relief from acute symptoms by the 4th day; 53.6% (95% confidence interval, range 70-37.1, P < 0.001) fewer patients had relapse in the antenatal period. Treatment was well accepted, and did not affect pregnancy, fetal development, birth weight, infant growth and feeding. In the short term, micronized diosmin 90% and hesperidin 10% is safe, acceptable, and effective in the treatment of hemorrhoids of pregnancy.

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Citations

Apr 8, 2011·World Journal of Gastroenterology : WJG·Ma-Mu-Ti-Jiang A Ba-bai-ke-reHao Wen
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Kee-Ming ManFeng-Fan Chiang
May 9, 2014·Archives of Gynecology and Obstetrics·Ayse Nur Cakir GungorEmine Cosar
Feb 17, 2005·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·A W N Meshikhes
Sep 24, 2004·Biomedical Chromatography : BMC·Feras Imad KanazeIoannis Niopas
Aug 10, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Chenlin ShenJun Li
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Ahmed H Al-JedaiRoaa A Algain
Apr 9, 2010·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A F Avsar, H L Keskin
Jun 30, 2005·Journal of Pharmaceutical and Biomedical Analysis·S TommasiniR Ficarra
Jun 11, 2015·Phlebology·Isabelle LacroixChristine Damase-Michel
Jan 23, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Seyed Hamdollah MosavatMojtaba Heydari
Dec 18, 2001·Phytotherapy Research : PTR·A GargA K Singla
Jan 12, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tingting LiSong Quan
Jul 22, 2005·The Cochrane Database of Systematic Reviews·C E Quijano, E Abalos
May 1, 2021·Journal of Comparative Effectiveness Research·Philippe GodebergeYury Shelygin
Jan 22, 2004·Journal of Agricultural and Food Chemistry·Angel Gil-IzquierdoFederico Ferreres
Apr 9, 2020·GE Portuguese Journal of Gastroenterology·Paulo SalgueiroFernando Castro-Poças

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