PMID: 8609463Feb 1, 1996Paper

Micronuclei in lymphocytes of children from the vicinity of Chernobyl before and after 131I therapy for thyroid cancer

International Journal of Radiation Biology
K WuttkeE Demidchik

Abstract

The present study addresses the monitoring of children from the Belorussian and Ukrainian Republics exposed to the fall-out of the Chernobyl accident. Micronucleus analysis has been performed on 56 children from different areas. The micronucleus frequencies in individuals as well as in regional groups were comparable with controls, except for three donors. Such results had to be expected, taking into account that at least 7 years have passed since the accident. Most of the children whose micronucleus frequencies were determined are suffering from thyroid cancer and were treated by radioiodine (131I) therapy. We studied the effect of in vitro exposure with 131I on micronucleus induction and that proliferative ability of lymphocytes. The present investigation indicates that micronuclei can be usefully employed to detect individual exposures to the incorporated radionuclide within several days after the intake of the radionuclide in a dose range of around 65-390 mGy (effective dose).

References

Apr 30, 1979·Radiation and Environmental Biophysics·A A EdwardsR J Purrott
Apr 1, 1990·International Journal of Radiation Biology·J Zoetelief, J J Broerse
May 1, 1988·Mutation Research·J S ProsserA A Edwards
Feb 1, 1985·Mutation Research·M Fenech, A A Morley
Jan 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D K KwanA Norman
Oct 1, 1993·Journal of Toxicology and Environmental Health·G K LivingstonH R Elson

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Citations

Feb 19, 2013·Cancer Biotherapy & Radiopharmaceuticals·Sanam AramiS Abolghasem Haeri
Oct 8, 2009·European Journal of Clinical Investigation·R ScarpatoI Sbrana
Jun 6, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·K WuttkeC Streffer
May 15, 2002·Radiation Research·Tung-Kwang LeeAlbert L Wiley
May 8, 2001·Nuclear Medicine Communications·M A MonsieursR A Dierckx
Nov 12, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Roberto ScarpatoGiovanni Federico
Jun 15, 2017·Radiation and Environmental Biophysics·Usha YadavB K Sapra

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