Micronuclei induction and chromosomal aberrations in Rattus norvegicus by chloroacetic acid and chlorobenzene

Ecotoxicology and Environmental Safety
Mohammad Faisal SiddiquiAbsar-ul Hasnain

Abstract

Chloroacetic acid (CAA) and chlorobenzene (CB) have been evaluated for in vivo mutagenic potential in Rattus norvegicus, employing the following criteria : (i) chromosomal aberrations (CAs) such as breaks, gaps, exchanges, rings, and multiple aberrations and (ii) micronuclei (MN) induction. Three sublethal doses, 0.008, 0.01, and 0.012 mg/g b. wt. of CAA and 0.75, 1.0, and 1.25 mg/g b. wt. of rat of CB were administered and the bone marrow cells evaluated in each of the three treated groups at 12, 24, and 48 h, respectively. Mean MN frequencies of 4.40+/-0.2 and 5.42+/-0.3, obtained respectively for CAA and CB. The higher induction of MN by CAA and CB was dose- and time-dependent. Most significant impact (P<0.05) for either of the compounds was observed at 24h post administration, when the recorded mean frequency of CAs was maximum for CAA (4.33+/-0.6) as well as for CB (4.66+/-0.5).

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Citations

Jul 11, 2009·Chemico-biological Interactions·Riaz AhmadAbsar-ul Hasnain
Nov 1, 2008·Environmental Toxicology and Pharmacology·Riaz AhmadAbsar-Ul Hasnain
May 14, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Takeshi MoritaMasamitsu Honma
May 13, 2020·Environmental Science and Pollution Research International·Mariel Alejandra TripodiOlga Virginia Suárez

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