PMID: 2113788Jan 1, 1990Paper

Micronutrient status and immune function in tuberculosis

Annals of the New York Academy of Sciences
D N McMurrayE Hernandez-Frontera

Abstract

Both macro- and micronutrients have been shown to affect resistance to tuberculosis, which is mediated by macrophages activated by T lymphocytes. Others have demonstrated inhibition of mycobacterial replication in macrophage cultures treated with vitamin D or retinoic acid. We examined the influence of dietary zinc and vitamin D on resistance to tuberculosis. Guinea pigs were fed diets containing varying levels of zinc or vitamin D, and infected 6 weeks later by the respiratory route with virulent Mycobacterium tuberculosis. Zinc-deficient guinea pigs had fewer circulating T cells and reduced tuberculin (PPD) hypersensitivity. The response of peritoneal exudate macrophages to the lymphokine MIF was impaired. Zinc deprivation did not influence disease resistance in BCG-vaccinated or nonvaccinated animals. Vitamin D deficiency adversely affected the tuberculin reaction and ability to control the infection. Lymphocytes from vitamin D-deprived animals did not proliferate normally when cultured with PPD. A diet supplemented with vitamin D enhanced T cell responses to PPD in vivo. These results suggest that zinc and vitamin D status affect immunity to tuberculosis.

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Citations

Mar 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·N KennedyS H Gillespie
Jun 3, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mark P Nicol, Robert J Wilkinson
Jun 7, 2017·Biological Trace Element Research·Mohammad Tariqur Rahman, Muhammad Manjurul Karim
Aug 1, 1994·Nutrition Reviews·J E Morley
Dec 9, 2000·The Journal of Nutrition·E KaryadiC E West
Sep 7, 2005·European Journal of Pediatrics·Anna ChallaStyliani Andronikou
Jun 10, 2015·The Journal of Biological Chemistry·Karrera Y DjokoAlastair G McEwan
Feb 9, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mark W TenfordeUNKNOWN NWCS319 and ACTG 5175 study team
Jan 14, 2017·Inflammopharmacology·Magdalena JaroszTadeusz Librowski
Feb 15, 2016·Current Environmental Health Reports·Daniele FerrarioThomas Hartung
May 8, 1999·The American Journal of Clinical Nutrition·R Vieth
Jan 26, 2021·Royal Society Open Science·George GriffinDavid Thickett
Jul 3, 2002·The Veterinary Journal·J M Pollock, S D Neill
Aug 7, 2002·International Journal of Cardiology·Klaus K A Witte, Andrew L Clark
Dec 4, 2003·Microbial Pathogenesis·W R WatersR L Horst

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