Micronutrients in Human Milk: Analytical Methods

Advances in Nutrition
Daniela HampelLindsay H Allen

Abstract

Exclusive breastfeeding is recommended by the WHO for the first 6 mo of life because human milk protects against gastrointestinal infections and supplies balanced and adequate nutrient contents to the infant. However, reliable data on micronutrient concentrations in human milk are sparse, especially because some micronutrients are affected by maternal diet. Microbiological and competitive protein-binding assays, nuclear magnetic resonance or inductively coupled plasma spectroscopy, and chromatographic analyses are among the methods that have been applied to human-milk micronutrient analysis. However, the validation or evaluation of analytical methods in terms of their suitability for the complex human-milk matrix has been commonly ignored in reports, even though the human-milk matrix differs vastly from blood, plasma, or urine matrixes. Thus, information on the validity, accuracy, and sensitivity of the methods is essential for the estimation of infant and maternal intake requirements to support and maintain adequate milk micronutrient concentrations for healthy infant growth and development. In this review, we summarize current knowledge on methods used for analyzing water- and fat-soluble vitamins as well as iron, copper, zin...Continue Reading

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Citations

Nov 26, 2019·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Rafael A Caparros-GonzalezMaria Isabel Peralta-Ramirez
May 28, 2020·Nutrients·Yarden Golan, Yehuda G Assaraf
Jul 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michela CodiniElisabetta Albi
Aug 6, 2019·Frontiers in Endocrinology·Daniele BarbaroVittorio Unfer
Jul 6, 2019·The American Journal of Clinical Nutrition·Kellie O CasavaleChristopher J Lynch
Mar 27, 2020·The Journal of Nutrition·Kyly C WhitfieldDaniela Hampel
Dec 10, 2020·Basic and Clinical Andrology·Safouane M HamdiStéphanie Albarede
Apr 9, 2021·The American Journal of Clinical Nutrition·Parul ChristianDaniel J Raiten
May 1, 2021·Antioxidants·Stefano LorenzettiInga C Teller
May 1, 2021·Organic & Biomolecular Chemistry·Shinichi YamabeShoko Yamazaki
Jun 26, 2021·Analytical and Bioanalytical Chemistry·Kelly A DingessBernd Stahl
Nov 19, 2021·Endocrine Reviews·Maria Andersson, Christian P Braegger

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