Microorganisms associated with epithelial surfaces and stability of the indigenous gastrointestinal microflora

Die Nahrung
D C Savage

Abstract

Indigenous microorganisms of many genera and species associate with mucosal epithelia in the gastrointestinal tracts of animals and humans. These mechanisms may involve a high degree of specificity for host and surface habitat. They may include a capacity of the microorganisms to adhere to the membranes of substratum epithelial cells, to colonize and utilize as a source of nutrients the mucus overlying epithelial cells, and to be motile and attracted into the mucous layer by chemotaxis. The microbes must be able as well to thrive in the nutritional and environmental conditions prevailing on the epithelial surfaces. Microbial communities associated with epithelial surfaces are critical for maintaining a microflora in areas of the tract (i.e., stomach, small intestine) where the lumenal content moves at a rate exceeding the maximum rates at which indigenous microorganisms can multiply. Such communities even may be important in areas (i.e., the cecum and colon) where the content moves at rates below those at which the microbes can multiply. In such areas, microorganisms colonizing mucus on the epithelium and in the crypts of Lieberkuhn may provide a stable inoculum for the lumenal content which may be altered in composition in tim...Continue Reading

References

Oct 1, 1977·Journal of Bacteriology·E P Greenberg, E Canale-Parola
Nov 1, 1977·Applied and Environmental Microbiology·A A SalyersT D Wilkins
Nov 1, 1977·The American Journal of Clinical Nutrition·S M FinegoldR L Phillips
Oct 1, 1969·The American Journal of Physiology·M H Khayat, J Christophe
May 1, 1983·Applied and Environmental Microbiology·T B Stanton, D C Savage
Jan 1, 1982·Advances in Experimental Medicine and Biology·A Silberberg, F A Meyer
Sep 1, 1981·Applied and Environmental Microbiology·C Huelsmann, D C Savage
Dec 1, 1967·Journal of Bacteriology·D C Savage, R J Dubos

Citations

Jul 15, 2004·Advances in Applied Microbiology·P Naaber, M Mikelsaar
Jul 20, 2010·Cell Host & Microbe·Minsoo KimChihiro Sasakawa
Sep 8, 2000·American Journal of Veterinary Research·K L JohnstonR M Batt
Sep 1, 1995·Veterinary Surgery : VS·J A HallD C Twedt
Apr 1, 1997·Journal of Gastroenterology and Hepatology·M YokotaM Kitajima
May 1, 1997·The Journal of Small Animal Practice·J A HallD C Twedt
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M Sanders
Jul 12, 2008·Scandinavian Journal of Gastroenterology·Peter Thelin SchmidtHans Törnblom
Dec 1, 1995·Digestive Diseases and Sciences·J D ChenR W McCallum
Apr 10, 2010·The Journal of Veterinary Medical Science·Kenkichi YamamotoHiroshi Kitagawa
May 4, 2010·Annals of Biomedical Engineering·Martin L BuistYong Cheng Poh
Dec 1, 1996·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M JiménezE E Daniel
Jun 22, 2014·The Journal of Physiology·K A HallK D Keef
Dec 17, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·John MalyszGianrico Farrugia
Oct 2, 2015·Bioscience Reports·Layanne Cabral da Cunha AraujoBagnólia Araújo da Silva
Feb 14, 2020·Science Translational Medicine·Candice R GurbatriTal Danino

Related Concepts

Metazoa
Bacterial Adhesion
Gastrointestinal System
Mesothelium
Structure of Pyloric Gland
Intestinal Motility
Structure of Intestinal Gland
Muscularis Mucosae

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.