Micropapillary variant of urothelial carcinoma in the upper urinary tract: a clinicopathologic study of 11 cases.

Archives of Pathology & Laboratory Medicine
Charles C GuoBogdan Czerniak

Abstract

Micropapillary urothelial carcinoma (MPUC) is a rare variant of urothelial carcinoma. Most studies of MPUC have focused on the urinary bladder, but MPUC of the upper urinary tract remains to be investigated. To investigate the pathologic features and clinical significance of MPUC in the upper urinary tract. We searched the pathology files at our institution and identified 11 cases of MPUC of the upper urinary tract. The histology slides were reviewed, and the clinical information was obtained by review of medical charts. The average age of the patients was 64.2 years (range, 22-76 years). The tumors were located in the renal pelvis (n = 5), ureter (n = 4), and ureteropelvic junction (n = 2). In all cases, MPUC accounted for an average of 45% (range, 10%-80%) of the tumor and was associated with conventional urothelial carcinoma. Lymphovascular invasion was present in all cases, and metastasis to lymph node was present in 4 of 5 patients whose lymph nodes were dissected. Two patients presented with pT2 disease, and both were alive without evidence of disease at 85 and 119 months after surgery. The other 9 patients presented with pT3 or pT4 disease: 4 of them died of disease at an average of 18 months; 4 surviving patients develo...Continue Reading

References

Mar 1, 1980·The Journal of Urology·R J Babaian, D E Johnson
Aug 1, 1994·Pathology, Research and Practice·S Luna-MoréC Luna
May 20, 1999·The Journal of Urology·S L JohanssonS Holmäng
Feb 26, 2000·Pathology International·Y L Oh, K R Kim
Apr 24, 2004·The American Journal of Surgical Pathology·Toshitaka NagaoJean E Lewis
May 22, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hind NassarVolkan Adsay
Oct 27, 2004·Advances in Anatomic Pathology·Hind Nassar
Jan 13, 2006·The Journal of Urology·Sten HolmängSonny L Johansson
Apr 28, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bisong HauptSteven S Shen
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

Mar 7, 2021·Genes·Elisa De LorenzisEmanuele Montanari
Feb 20, 2019·Urologic Oncology·Jonathan J DupliseaSurena F Matin
Sep 22, 2009·Pathology, Research and Practice·Aleksandr M Perepletchikov, Anil V Parwani
Apr 27, 2010·Advances in Anatomic Pathology·Katherine E Watts, Donna E Hansel
Aug 19, 2010·The American Journal of Surgical Pathology·Ankur R SangoiJesse K McKenney

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