Microparticle formation and its mechanism in single and double emulsion solvent evaporation

Journal of Controlled Release : Official Journal of the Controlled Release Society
Iosif Daniel RoscaMotohiro Uo

Abstract

The emulsification is the first step of the emulsification solvent evaporation method and has been extensively investigated. On the contrary the second step, the solvent transport out from the emulsion droplets that determine the particle morphology and with great influence on the microparticles encapsulation and release behavior has been scarcely studied. This study investigates the mechanism of the solvent elimination from the emulsion droplets and its influence on the particle morphology, encapsulation and release behavior. Usually, the solvent is highly volatile that makes the solvent elimination process very fast thus difficult to observe. In order to observe in detail the microparticle formation, the initial emulsion was monitored by optical microscope under controlled solvent evaporation conditions. The results from the optical microscopic observations corroborated with laser diffractometry analysis showed that in single emulsion formulations, spherical microparticles are formed by accelerated solvent elimination due to the combined effects of high solvent volatility and polymer precipitation. The solvent expulsion accompanied by important shrinkage generates on the microparticle surface a thin layer of nanoparticles att...Continue Reading

References

Nov 5, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·J M PéanJ P Benoit
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y CapanP P DeLuca
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·D T BirnbaumL Brannon-Peppas
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K S SoppimathW E Rudzinski
Jun 29, 2001·Journal of Microencapsulation·Y Y Huang, T W Chung
Jul 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y Y YangJ Heller
Jan 29, 2002·Journal of Microencapsulation·M R AberturasF García
Dec 20, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Mu, S S Feng
Nov 7, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Grégoire SchwachRobert Gurny

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Citations

Sep 8, 2010·Chemical Communications : Chem Comm·Mi Ri KimKuk Young Cho
Nov 14, 2013·Antioxidants & Redox Signaling·Elena ArriazuNatalia Nieto
Apr 15, 2009·Journal of the Royal Society, Interface·Fumio WatariKazuyuki Tohji
Aug 25, 2012·Investigative Ophthalmology & Visual Science·Song-Qi GaoKrzysztof Palczewski
Aug 27, 2013·International Journal of Nanomedicine·Maedeh ZamaniSeeram Ramakrishna
Aug 17, 2011·International Journal of Molecular Sciences·Lydia FrancisIpsita Roy
Dec 18, 2013·International Journal of Pharmaceutics·Nadiah ZafarAbdelhamid Elaissari
Apr 1, 2014·International Journal of Pharmaceutics·Kieran KeohaneBrendan T Griffin
Sep 1, 2014·International Journal of Pharmaceutics·Rajendar R MallepallyKevin R Ward
Apr 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Lalmoddin MollahHye-Jin Park
Apr 18, 2014·Journal of Microencapsulation·Maria Antonietta CasadeiFederica Vitali
Mar 2, 2012·Journal of Microencapsulation·Ujwala A ShindeKavita H Singh
Jun 12, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Etienne MaraisJan Steenekamp
Jun 6, 2008·Expert Opinion on Drug Delivery·S Dean Allison
May 1, 2012·Drug Development and Industrial Pharmacy·Nahla S BarakatAzza H Almedany
Apr 28, 2006·Expert Opinion on Drug Delivery·Omid C FarokhzadRobert Langer
Feb 27, 2010·Drug Development and Industrial Pharmacy·M E MoralesV Gallardo
Dec 4, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Gitu PandeyBrahmeshwar Mishra
Aug 15, 2014·Journal of Pharmaceutical Sciences·Yang CaoDeshuai Lou
Sep 26, 2009·Journal of Pharmaceutical Sciences·G Della PortaE Reverchon
May 11, 2012·Journal of Pharmaceutical Sciences·Wei Li LeeSay Chye Joachim Loo
Feb 5, 2013·International Journal of Pharmaceutics·K MiladiA Elaissari
May 18, 2010·International Journal of Pharmaceutics·Archana Rawat, Diane J Burgess
Jun 2, 2009·International Journal of Pharmaceutics·Desiree KietzmannAlf Lamprecht
May 12, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Aurélie Malzert-FréonFrank Boury
Apr 28, 2009·Journal of Colloid and Interface Science·Li LiuLiang-Yin Chu
Mar 24, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nicoleta ButoescuEric Doelker
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·T S DeminaCh Grandfils
Jun 28, 2008·Acta Biomaterialia·A M ZalfenB Evrard
Sep 12, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Robert F Pagels, Robert K Prud'homme
Dec 25, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yiquan WuRobert L Clark

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