PMID: 11336852May 5, 2001Paper

Microperfusion enhancement after TMLR in chronically ischemic porcine hearts

Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery
G LutterF Beyersdorf

Abstract

The purpose of this study was to determine the effect of transmyocardial laser revascularization (TMLR) on myocardial perfusion and function in chronically ischemic myocardium. In the first operation a stenosis of the left anterior descending artery was created in 20 open-chest anesthetized pigs to implement this ischemic model. In contrast, four pigs served as controls (thoracotomy only). Seven days later (2nd operation), all animals were studied at baseline by analyzing different parameters of perfusion (radioactive microspheres), function, and intramyocardial pressure. Afterwards, pigs who received a left anterior descending artery stenosis were randomized into one of three groups: animals in laser group 1 (n=7) received one and in laser group 2 (n=7) two laser channels per cm(2) in the left anterior descending artery territory. Animals of the ischemic group (n=6) underwent the same procedures without transmyocardial laser revascularization. Three months later, the animals were re-studied (3rd operation) and additional analysis of histochemistry and myocardial water content was performed. Regional myocardial blood flow (RMBF) in laser group 2 revealed statistically higher RMBF values compared to the ischemic group (0.39+/-0....Continue Reading

References

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Citations

Sep 20, 2002·The Annals of Thoracic Surgery·Menno HuikeshovenMartin J C van Gemert
Jan 1, 2010·Multimedia Manual of Cardiothoracic Surgery : MMCTS·Hans Michael KleinMichael Heke
Apr 26, 2008·Journal of Cardiac Surgery·Keith A Horvath

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