Microphthalmia transcription factor in malignant melanoma predicts occult sentinel lymph node metastases and survival

Melanoma Research
Samer NaffoujeGeorge I Salti

Abstract

Microphthalmia transcription factor (Mitf) is involved in melanocyte development and differentiation. We previously reported that Mitf expression, as detected by immunohistochemical analysis, is an independent prognostic marker in patients with intermediate-thickness melanoma. However, the clinical significance of Mitf expression in melanoma is not well delineated. In this prospective study, we attempted to demonstrate the correlation between Mitf expression in primary melanoma and the sentinel lymph node status and prognosis. We prospectively examined primary cutaneous melanomas from 94 patients undergoing nodal staging by sentinel lymph node biopsy. We quantified the percentage of tumor cells whose nuclei stained with the Mitf antibody visually. Survival curves were generated using the Kaplan-Meier method. The correlation between Mitf expression and nodal status was evaluated using the Mann-Whitney U-test. Here we demonstrate that Mitf expression is directly correlated with both disease-free survival (DFS) and overall survival (OS) over a median follow-up of 28.5 months. The mean DFS and OS in the eight patients whose melanomas did not stain positive for Mitf were 15.75±3.36 months (median, 12 months) and 38.17±5.18 months (m...Continue Reading

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Citations

Apr 16, 2016·World Journal of Clinical Oncology·Dale HanStanley Pl Leong
Aug 23, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Philipp JurmeisterMaximilian von Laffert
Aug 23, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Philipp JurmeisterMaximilian von Laffert
Mar 2, 2018·Oncotarget·Maria Cristina SiniGiuseppe Palmieri
May 21, 2020·International Journal of Molecular Sciences·Kevin YangAndrzej T Slominski

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS

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