Microplastics Aggravate the Bioaccumulation of Two Waterborne Veterinary Antibiotics in an Edible Bivalve Species: Potential Mechanisms and Implications for Human Health

Environmental Science & Technology
Weishang ZhouGuangxu Liu

Abstract

Edible bivalves are one of the major types of seafood and may be subject to antibiotic and microplastics (MPs) coexposure under realistic scenarios. However, the effect of MPs on the bioaccumulation of antibiotics in edible bivalves and subsequent health risks for consumers remain poorly understood. Therefore, the bioaccumulation of two frequently detected veterinary antibiotics, oxytetracycline (OTC) and florfenicol (FLO), with or without the copresence of MPs was investigated in the blood clam. Health risks associated with the consumption of contaminated clams were also assessed. Furthermore, the activity of GST and expression of key detoxification genes were analyzed as well. The bioaccumulation of OTC and FLO in clams was found to be aggravated by MPs. Because the estimated target hazard quotients (THQs) were far less than the critical value, direct toxic effects of consuming contaminated clams are negligible. However, the dietary exposure doses of the human gut microbiota (DEGM) to the antibiotics tested were greater than or similar to corresponding minimum selective concentrations (MSC), indicating a potential antibiotic resistance risk. Moreover, the GST activity and expression of detoxification genes were significantly ...Continue Reading

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Citations

Jan 15, 2021·Journal of Hazardous Materials·Wei ShiGuangxu Liu
Apr 6, 2021·Journal of Environmental Management·Minghan ZhuTingting Zhang
Nov 14, 2020·Particle and Fibre Toxicology·Nell Hirt, Mathilde Body-Malapel
Jun 25, 2021·Chemosphere·Anabel González-AcedoVíctor Javier Costela-Ruiz
Jul 7, 2021·Environmental Science and Pollution Research International·Huu Cong Vo, Minh Hen Pham
Oct 11, 2021·The Science of the Total Environment·Guanglong ChenJun Wang
Oct 30, 2021·Environmental Science and Pollution Research International·Jiarui LuYide He

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