Microporenic Acids A-G, Biofilm Inhibitors, and Antimicrobial Agents from the Basidiomycete Microporus Species

Journal of Natural Products
Clara ChepkiruiMarc Stadler

Abstract

The need for effective compounds to combat antimicrobial resistance and biofilms which play important roles in human infections continues to pose a major health challenge. Seven previously undescribed acyclic diterpenes linked to isocitric acid by an ether linkage, microporenic acids A-G (1-7), were isolated from the cultures of a hitherto undescribed species of the genus Microporus (Polyporales, Basidiomycota) originating from Kenya's Kakamega forest. Microporenic acids D and E (4 and 5) showed antimicrobial activity against a panel of Gram positive bacteria and a yeast, Candida tenuis. Moreover, microporenic acids A and B (1 and 2) demonstrated dose-dependent inhibition of biofilm formation by Staphylococcus aureus. Compound 1 further showed significant activity against Candida albicans and Staphylococcus aureus preformed biofilms.

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Citations

Mar 20, 2019·Natural Product Research·Wan-Rong NiuXiao-Yan Yang
Jan 24, 2020·Chembiochem : a European Journal of Chemical Biology·Rieke HimstedtPeter Spiteller
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chayanard PhukhamsakdaMarc Stadler
Jan 11, 2020·Beilstein Journal of Organic Chemistry·Soleiman E HelalyMarc Stadler
Oct 25, 2020·The Journal of Antibiotics·Kevin Becker, Marc Stadler
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Blondelle Matio KemkuignouMarc Stadler
May 12, 2021·Journal of Natural Products·Divinah K NyambokiJosphat C Matasyoh
Apr 20, 2019·Journal of Natural Products·Tian ChengMarc Stadler
Jul 17, 2019·Journal of Agricultural and Food Chemistry·Clara ChepkiruiMarc Stadler
Aug 14, 2020·Journal of Natural Products·Tian ChengMarc Stadler
Aug 23, 2021·Chinese Journal of Natural Medicines·Fu-Juan SunMing-Hua Yang

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