Microrheology with optical tweezers: measuring the relative viscosity of solutions 'at a glance'

Scientific Reports
Manlio TassieriJonathan M Cooper

Abstract

We present a straightforward method for measuring the relative viscosity of fluids via a simple graphical analysis of the normalised position autocorrelation function of an optically trapped bead, without the need of embarking on laborious calculations. The advantages of the proposed microrheology method are evident when it is adopted for measurements of materials whose availability is limited, such as those involved in biological studies. The method has been validated by direct comparison with conventional bulk rheology methods, and has been applied both to characterise synthetic linear polyelectrolytes solutions and to study biomedical samples.

References

Feb 13, 1995·Physical Review Letters·T G Mason, D A Weitz
Jun 13, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Bivash R DasguptaD A Weitz
Dec 11, 2007·Biophysical Journal·M TassieriT A Waigh
Dec 31, 2008·Physical Review Letters·Manlio TassieriTom A Waigh
Aug 19, 2009·Biophysical Journal·Susana FrasesArturo Casadevall
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Manlio TassieriJonathan M Cooper
Nov 24, 2011·Physical Review Letters·François BoyerOlivier Pouliquen
Jun 22, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Angelo PommellaManlio Tassieri
Jul 16, 2013·Physical Review Letters·Jérémie GachelinEric Clément

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Citations

Aug 2, 2016·Biomicrofluidics·Siddhartha GuptaSiva A Vanapalli
Jan 27, 2017·Annual Review of Food Science and Technology·Nan YangYapeng Fang
Aug 3, 2018·Small·Tommy Garting, Anna Stradner
Jul 30, 2015·Molecular Pharmacology·Yu Ri JungMinyoung Lee
Jun 2, 2016·Reports on Progress in Physics·Thomas Andrew Waigh
Sep 25, 2019·Nature Methods·Robert PrevedelGiuseppe Antonacci
Sep 15, 2015·Applied Optics·Sławomir Drobczynski, Jakub Ślęzak
Sep 30, 2015·Biomedical Optics Express·Dipankar Mondal, Debabrata Goswami
Oct 19, 2017·Optics Express·Stijn VandewieleFilip Beunis
Jun 17, 2020·Applied Optics·Shruthi Subhash IyengarSarbari Bhattacharya
Jan 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Òscar GuadayolStuart Humphries
Mar 12, 2021·Scientific Reports·Andrew B MathesonPaul A Dalgarno
May 1, 2021·Sensors·Witold K SzeremetaMassimo Antognozzi
Jul 8, 2021·Scientific Reports·Randhir KumarCornelia Denz

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Methods Mentioned

BETA
rheology
optical tweezers

Software Mentioned

Ubbelohde
LabVIEW

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