MicroRNA-1258: An invasion and metastasis regulator that targets heparanase in gastric cancer.

Oncology Letters
Jinxin ShiZhenning Wang

Abstract

Numerous microRNAs (miRNAs/miRs) are involved in suppressing or promoting the formation of cancer. However, to the best of our knowledge, the role of miRNA-1258 in gastric cancer (GC) has not previously been investigated. Our previous study demonstrated an increased expression of heparanase (HPSE) in GC tissues and HPSE-facilitated invasion and metastasis of GC cells. Consequently, in the present study, the function of miR-1258 in the invasion and metastasis of GC cells was investigated to determine whether miR-1258 is associated with GC through HPSE. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to determine miR-1258 expression in GC cell lines and tissues. A Transwell cell invasion assay and an MTT proliferation assay were used to investigate the effects of miR-1258 on the invasion and proliferation of one of the cell lines, SGC-7901 cells, in vitro. The effect of miR-1258 on SGC-7901 cell metastasis was investigated using an in vivo tumor metastasis formation assay. Western blot analysis and RT-qPCR were used to investigate whether HPSE was a target of miR-1258 in GC. The expression of miR-1258 was significantly downregulated in 3 GC cell lines and 116 GC tissues compared with controls (all ...Continue Reading

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Citations

Apr 10, 2018·Cancer Biomarkers : Section a of Disease Markers·Yuanyu WuXuedong Fang
Aug 16, 2019·Investigational New Drugs·Dongying LiuYi Ba
Dec 13, 2019·Journal of Experimental & Clinical Cancer Research : CR·Yongjun LuoWeihua Cai
Nov 6, 2017·Cancer Biomarkers : Section a of Disease Markers·Handong SunXiufeng Cao
Jan 10, 2020·Experimental and Molecular Pathology·Xing PengChunyan Cai
Jan 26, 2021·OncoTargets and Therapy·Dorival Mendes Rodrigues-JuniorMaria Aparecida Silva Pinhal
Mar 31, 2020·European Journal of Medicinal Chemistry·Kaishuo FuWen Zhou
Feb 10, 2019·Biochemical and Biophysical Research Communications·Wei LiuWeihua Cai

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