MicroRNA-125a-3p downregulation correlates with tumorigenesis and poor prognosis in patients with non-small cell lung cancer

Oncology Letters
Likun HouDa Fu

Abstract

MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omnibus database was used to analyze miR-125a-3p expression in NSCLC in silico, and 148 NSCLC samples and 30 adjacent normal lung tissue specimens were analyzed for the expression of miR-125a-3p by qPCR. The results showed that the expression levels of miR-125a-3p in the adjacent normal tissues was higher than the expression level in the NSCLC tissues. There were several clinical parameters demonstrated to be associated with miR-125a-3p expression, such as lymph node metastasis, tumor node metastasis classification of malignant tumor stage and tumor diameter. Furthermore, high expression levels of miR-125a-3p with chemotherapy prolonged the overall survival rate and disease free survival rate compared with untreated patients with low expression of miR-125a-3p. Thus, miR-125a-3p is a significant prognostic biomarker for patients with NSCLC, from which a novel therapeutic strategy to combat NSCLC may be derived.

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Citations

Aug 6, 2019·The International Journal of Biological Markers·Xiqi PengYongqing Lai
Feb 13, 2020·Journal of Translational Medicine·Li-Zhong LiuMing-Yue Li
Jun 7, 2020·Journal of Gastrointestinal Cancer·Mônica Pezenatto Dos SantosLucas Trevizani Rasmussen
Mar 1, 2019·Cancers·Shang-Gin WuJin-Yuan Shih
May 1, 2019·Anti-cancer Agents in Medicinal Chemistry·Abbas J AvvalGhasem Ahangari

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Datasets Mentioned

BETA
GSE16025
GSE24709

Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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