MicroRNA-125a-5p enhances the sensitivity of esophageal squamous cell carcinoma cells to cisplatin by suppressing the activation of the STAT3 signaling pathway

International Journal of Oncology
Yan ZhaoQingxia Fan

Abstract

Increasing evidence has demonstrated that microRNAs (miRNAs or miRs) play a variety of roles in tumor development, progression and chemosensitivity in a wide range of tumors. In this study, we found that miR‑125a‑5p exhibited a low expression in esophageal squamous cell carcinoma (ESCC) tissues and cells, and that its low expression was associated with higher tumor staging and shorter a survival time of patients with ESCC. Moreover, miR‑125a‑5p overexpression contributed to the suppression of cell proliferation, cell cycle arrest, cell apoptosis and a decrease in cell migratory and invasive abilities, whereas the downregulation of miR‑125a‑5p promoted cell proliferation, accelerated cell cycle progression, suppressed apoptosis and enhanced the migratory and invasive abilities of ESCC EC1 and TE1 cells, which may be tightly associated with the epithelial‑mesenchymal transition (EMT) process in ESCC. Importantly, miR‑125a‑5p enhanced the cytotoxic effects of cisplatin on EC1 and TE1 cells, and co‑treatment with miR‑125a‑5p and cisplatin significantly induced cell apoptosis and reduced the cell migratory and invasive abilities of EC1 and TE1 cells, coupled with an increase in the E‑cadherin level and a decrease in the N‑cadherin a...Continue Reading

Citations

Apr 9, 2020·Frontiers in Pharmacology·Jiabei ZhouLushan Yu
Jan 8, 2020·International Journal of Molecular Sciences·Qingqing FengYan-Dong Wang
Oct 27, 2020·Expert Review of Molecular Diagnostics·Esmat AbdiZahra Taherian-Esfahani
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuelong ZhangQi Zhang

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Methods Mentioned

BETA
surgical resection
transfection
PCR
Protein Assay
flow cytometry

Software Mentioned

ImageJ
miRanda
GraphPad Prism
miRDB
TargetScan

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