MicroRNA-125b Interacts with Foxp3 to Induce Autophagy in Thyroid Cancer

Molecular Therapy : the Journal of the American Society of Gene Therapy
Shanshan WangGeorge G Chen

Abstract

Thyroid cancer is rapidly increasing in incidence worldwide. Although most thyroid cancer can be cured with surgery, radioactive iodine, and/or chemotherapy, thyroid cancers still recur and may become chemoresistant. Autophagy is a complex self-degradative process that plays a dual role in cancer development and progression. In this study, we found that miR-125b was downregulated in tissue samples of thyroid cancer as well as in thyroid cancer cell lines, and the expression of Foxp3 was upregulated. Further, we demonstrated that miR-125b could directly act on Foxp3 by binding to its 3' UTR and inhibit the expression of Foxp3. A negative relationship between miR-125b and Foxp3 was thus revealed. Overexpression of miR-125b markedly sensitized thyroid cancer cells to cisplatin treatment by inducing autophagy through an Atg7 pathway in vitro and in vivo. Taken together, our findings demonstrate a novel mechanism by which miR-125b has the potential to negatively regulate Foxp3 to promote autophagy and enhance the efficacy of cisplatin in thyroid cancer. miR-125 may be of therapeutic significance in thyroid cancer.

Citations

Jan 23, 2019·Endocrine-related Cancer·Weijun WeiQuan-Yong Luo
Feb 1, 2019·Cancers·Marijke I ZonneveldKasper M A Rouschop
Jun 20, 2020·Expert Opinion on Therapeutic Targets·Shanshan WangGeorge G Chen
Dec 18, 2020·Cell Proliferation·Boya PengMinh T N Le
Apr 10, 2021·Biochemical and Biophysical Research Communications·Jing WangZhifeng Bai
Jun 17, 2021·Pediatric Blood & Cancer·Hossam El-Din A AbdelhafeezAhmed F Soliman
Sep 1, 2021·Reviews in Endocrine & Metabolic Disorders·Zhongqin GongGeorge G Chen

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