MicroRNA-125b is involved in atherosclerosis obliterans in vitro by targeting podocalyxin

Molecular Medicine Reports
Xiaobing LiZhenjiang Liu

Abstract

Cardiovascular disease associated with oxidative stress, including atherosclerosis, is the leading cause of mortality worldwide. The accelerated proliferation and migration of vascular smooth muscle cells are the predominant characteristics of atherogenesis, and endothelial dysfunction is a major risk factor for the pathogenesis of atherosclerosis. Podocalyxin (PODXL), a type I member of the cluster of differentiation 34 family of sialomucins, functions as a pro-adhesive molecule. Emerging evidence has revealed the importance of micro (mi)RNAs in the cardiovascular system. The present study demonstrated that there was an inverse association between miRNA (miR)-125b and PODXL in human umbilical vein endothelial cells and human aortic vascular smooth muscle cells (HAVSMCs) treated with oxidized low‑density lipoprotein (LDL) and platelet derived growth factor. Additionally, miR-125b had a suppressive function in cell proliferation and migration, at least partially via targeting PODXL in the HAVSMCs. Furthermore, the data suggested that the functions of miR-125b in arteriosclerosis obliterans may be associated with transgelin, lectin-type oxidized LDL receptor-1, vascular endothelial-cadherin, intercellular adhesion molecule-1, int...Continue Reading

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Citations

Feb 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xianming SuJie Kang
Jul 14, 2019·Journal of Cellular and Molecular Medicine·Chia-Ter ChaoHuei-Wen Chen
Jan 17, 2020·International Journal of Molecular Sciences·Alessia MongelliCarlo Gaetano
Apr 4, 2017·Cardiovascular Therapeutics·Su-Jie JiaMing Zhao
Jan 18, 2017·BioMed Research International·Xiao LinYou-Shuo Liu
Sep 11, 2020·Cardiovascular Diabetology·Karima Ait-AissaModar Kassan
Jul 18, 2017·Molecular Medicine Reports·Xueqin WangXiangyu Zhou
May 13, 2018·Bioscience Reports·Xueqin WangXiangyu Zhou
Aug 12, 2018·Journal of Molecular and Cellular Cardiology·Callum J DonaldsonLingfang Zeng

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