MicroRNA-125b suppresses the migration and invasion of hepatocellular carcinoma cells by targeting transcriptional coactivator with PDZ-binding motif

Oncology Letters
Jipeng LiYiping Wang

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that serve an important function in carcinogenesis and tumor progression. The present study investigated the roles and mechanisms of miRNA-125b (miR-125b) in human hepatocellular carcinoma (HCC). miR-125b was significantly downregulated in the examined HCC tissues and cell lines. Overexpression of miR-125b reduced HCC cell migration and invasion. By contrast, inhibition of miR-125b expression significantly accelerated HCC cell migration and invasion. In addition, the present study identified transcriptional coactivator with PDZ-binding motif (TAZ) as a functional downstream target of miR-125b. Furthermore, overexpression of TAZ impaired miR-125b-induced inhibition of invasion in HCC cells. The current study demonstrated that miR-125b may be involved in the tumorigenesis of HCC at least in part by the suppression of TAZ.

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Citations

Apr 27, 2016·European Journal of Pharmacology·Zhaoe LiuGang Li
May 7, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shanshan ChenJiancheng Tu
Jul 15, 2016·Protein & Cell·Xin Zhou, Qun-Ying Lei
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Apr 4, 2021·Biomedicines·Na-Hyun LeeJeongeun Hyun
May 1, 2021·Clinics and Research in Hepatology and Gastroenterology·Minghao YangXiao Cui
Aug 24, 2021·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Wen-Ting ZhangManuel Romero-Gómez

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Methods Mentioned

BETA
surgical resection
transfection
PCR
Assay
electrophoresis

Software Mentioned

TargetScan
SPSS

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