MicroRNA-126: a promising novel biomarker in peripheral blood for diabetic retinopathy

International Journal of Ophthalmology
Li-Li QinZhi-Qing Lu

Abstract

To investigate the content of serum microRNA-126 (miR-126) and its role in screening retinal endothelial injury and early diagnosis of proliferative diabetic retinopathy. The study included 184 serum samples, 59 samples from healthy individuals, 44 samples from diabetes mellitus (DM) patients without diabetic retinopathy (NDR), 42 from non-proliferative diabetic retinopathy (NPDR) patients and 39 samples from proliferative diabetic retinopathy (PDR) patients. The expression of miR-126 was evaluated using a real-time quantitative polymerase chain reaction. The serum content of miR-126 declined as the damage degree in the retina. There was significant difference between the two retinopathy groups (P<0.001). No difference was observed in miR-126 content between healthy individuals and NDR patients (P>0.05). Receiver operating characteristic curve (ROC) analyses indicated that serum miR-126 had significant diagnostic value for PDR. It yielded an area under the curve (AUC) of ROC of 0.976 with 81.21% sensitivity and 90.34% specificity in discriminating PDR from healthy controls, and an AUC of ROC of 0.919 with 84.75% sensitivity and 94.41% specificity in discriminating NDR and NPDR from healthy controls. When the diagnostic threshol...Continue Reading

Citations

Dec 18, 2018·Journal of Cellular Biochemistry·Mahbobeh SatariZatollah Asemi
Jan 23, 2020·International Journal of Molecular Sciences·Chi-Hsiu LiuJing Chen
Oct 15, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xiujuan ChenGuoping Cao
May 1, 2018·International Journal of Endocrinology·F BaruttaG Gruden
Aug 28, 2020·Frontiers in Endocrinology·Marta GrecoAntonio Brunetti
Sep 24, 2020·Antioxidants·Ana Karen López-ContrerasAdolfo Daniel Rodríguez-Carrizalez

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