MicroRNA-1299 is a negative regulator of STAT3 in colon cancer

Oncology Reports
Yong WangWei Zhao

Abstract

Signal transducers and activators of transcription (STAT) is a family of transcription factors which regulate cell proliferation, differentiation, apoptosis, metastasis, immune and inflammatory responses, and angiogenesis. STAT3 is a latent cytoplasmic transcription factor that belongs to STATs. STAT3 has been reported be regulates genes involved with cellular growth, proliferation and metastasis. Worldwide, colon cancer is one of the leading causes of cancer-related deaths. Cumulative evidence has established that STAT3 is essential for colon cancer progression to advanced malignancy. In our study, we showed that microRNA-1299 (miR-1299) was closely related to the TNM stage of colon cancer, and that the expression of miR-1299 was negatively correlated with the expression of STAT3 in colon cancer which means that miR-1299 can be a negative regulator of STAT3 in colon cancer. A total of 60 cases of different grades of colon samples were used to detect the expression of miR-1299. Results showed that miR-1299 was significantly lower in high-grade colons both in mRNA and protein levels. Furthermore, Overall survival (OS) in patients with low miR-1299 is shorter than 25.6 months, as compared with an OS of 28.4 months in patients wit...Continue Reading

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Citations

Sep 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin ZhangJie Zhang
Sep 20, 2017·Journal of Cellular Physiology·Shi-Min Chang, Wei-Wei Hu
Jun 30, 2019·World Journal of Gastroenterology : WJG·Zhen-Hua YangGuang Ji
Aug 4, 2018·Molecular Cancer Research : MCR·Meixiang SangCuizhi Geng
Jan 30, 2021·Computational and Structural Biotechnology Journal·Abhijit DasguptaRajat K De
Dec 17, 2020·Cancers·Tomasz M GrzywaPaweł K Włodarski
Apr 19, 2021·Cancer Cell International·Yufei TangFenggang Hou
May 4, 2021·Frontiers in Cardiovascular Medicine·Don M MatshaziTandi E Matsha
May 29, 2021·Future Science OA·Deng KaiyuanZang Yunhui
Sep 23, 2021·Journal of Cellular and Molecular Medicine·Sisi GuanWenjuan Zhang

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Methods Mentioned

BETA
transfection
PCR
Assay
flow cytometry

Software Mentioned

miRDB

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