MicroRNA-1301 inhibits migration and invasion of osteosarcoma cells by targeting BCL9

Gene
Lei WangYu Chao

Abstract

Increasing reports demonstrated that miRNAs play a critical role in tumor development and progression. Previous studies revealed that miR-1301 was abnormally expressed in various cancers. However, its function and underlying mechanism in osteosarcoma (OS) remains unknown. In this study, miR-1301 expression was significantly down-regulated in both OS tissues and cell lines. Down-regulated miR-1301 was obviously associated with malignant clinical features and poor overall survival of OS patients. miR-1301 overexpression inhibited cell proliferation, migration and invasion. In addition, we identified BCL9 act as a direct target of miR-1301 by directly binding to its 3'-UTR. In clinical OS tissues, miR-1301 negatively correlated BCL9 expression. BCL9 was up-regulated in OS tissues and cells. BCL9 overexpression promoted OS progression. Moreover, restoration of BCL9 expression at least partially abolished the proliferation, migration and invasion of miR-1301 on OS cells. In conclusion, our data indicated that miR-1301 inhibited cell proliferation, migration and invasion of OS by targeting BCL9, and may represent a novel potential therapeutic target and prognostic marker for OS.

Citations

Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
Aug 7, 2019·Bioscience Reports·Hua ZhangShandi Zhang
Jan 21, 2020·Cancer Science·Jiajia LiuXin Jin
May 3, 2019·Cancer Cell International·Jianhui ShiYansong Wang
Apr 2, 2020·IUBMB Life·Zeinab JamaliHamed Mirzaei
Jan 18, 2021·American Journal of Otolaryngology·De-Hui QiaoXiang-Yu Zhou
Feb 10, 2019·Biochemical and Biophysical Research Communications·Wei LiuWeihua Cai
Mar 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xueli WangLei Wang

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