MicroRNA-134 modulates resistance to doxorubicin in human breast cancer cells by downregulating ABCC1

Biotechnology Letters
Lin LuXuezhen Ma

Abstract

To investigate the role of microRNAs in doxorubicin resistance of breast cancer cells. MicroRNA-134 was down-regulated in doxorubicin-resistant and doxorubicin-sensitive breast cancer samples and MCF-7/ADR cell lines. After transfection of miR-134 mimics, an MTT assay confirmed that the MCF-7/ADR cell proliferation was inhibited. In the presence of doxorubicin, there was inhibition of cell proliferation. Transfection of miR-134 mimics induced MCF-7/ADR cell apoptosis. The expression of ABCC1 was significantly upregulated in doxorubicin-resistant or -sensitive breast cancer tissues and MCF-7/ADR cell lines. Over-expression of miR-134 decreased the expression of ABCC1 at the protein level. MicroRNA-134 modulates resistance to doxorubicin in breast cancer cells by downregulating the expression of ABCC1 which is known to encode the multidrug resistance-associated protein 1.

References

Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George W SledgeWilliam C Wood
Nov 6, 2003·Clinical Orthopaedics and Related Research·S M AliAllan Lipton
Oct 18, 2007·British Journal of Cancer·T GamucciL Meliffi
Feb 28, 2009·Clinical Chemistry·Claudine L Bartels, Gregory J Tsongalis
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marilena V Iorio, Carlo M Croce
Apr 8, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Linlang GuoYing Guo
Jul 14, 2010·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Mao Liu, Huiping Chen
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 24, 2011·The Cancer Journal·Valentina FodaleEmanuel Petricoin
Apr 25, 2012·Current Treatment Options in Oncology·Carrie Marquette, Lisle Nabell
Jun 13, 2012·Carcinogenesis·Hansjuerg AlderLouise Y Y Fong
Jul 13, 2012·Cell Cycle·Sumitaka YamanakaFlorin M Selaru
Aug 7, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M S N Mohd SharialB T Hennessy
Mar 8, 2013·International Journal of Oncology·Chao Shi NiuChuan-Dong Cheng
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Luca MagnaniMathieu Lupien
Oct 24, 2013·Molecular Oncology·Suvi-Katri LeivonenMerja Perälä
Jun 19, 2014·International Journal of Molecular Medicine·Yanhong LiWei Zhang
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Dec 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M S N Mohd SharialB T Hennessy

❮ Previous
Next ❯

Citations

Feb 15, 2016·Clinical Pharmacology and Therapeutics·F Fanini, M Fabbri
Jul 28, 2016·Expert Opinion on Drug Metabolism & Toxicology·Elena ArrigoniAntonello Di Paolo
Sep 1, 2016·Expert Opinion on Drug Metabolism & Toxicology·Takeshi HirotaIchiro Ieiri
Sep 16, 2016·Journal of Translational Medicine·Maria AmorimCarmen Jerónimo
Jun 16, 2017·Journal of Cellular Physiology·Hamed MirzaeiMahmoud Reza Jaafari
Dec 29, 2019·Journal of Applied Toxicology : JAT·Yimin SunJian Yin
May 7, 2020·International Journal of Molecular Sciences·Karol BukowskiRenata Kontek
Jun 8, 2018·Journal of Neuro-oncology·Yaomin LiSongtao Qi
Apr 3, 2020·Anti-cancer Agents in Medicinal Chemistry·Zhuo MaGuoqing Zhao
Apr 17, 2021·Cancer Cell International·Amir Sadra ZangoueiMeysam Moghbeli
May 5, 2021·The Journal of Pharmacy and Pharmacology·Khadijeh JamialahmadiGholamreza Karimi
Sep 16, 2021·Cancer Metastasis Reviews·Iris Garrido-CanoPilar Eroles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.