MicroRNA-135a inhibits cardiac fibrosis induced by isoproterenol via TRPM7 channel

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yan WuYi-Qun Tang

Abstract

Cardiac fibrosis is a crucial factor of heart failure. It has been reported that several microRNAs (miRNAs, miRs) were involved in cardiac fibrosis, however, the role and possible regulatory mechanism of microRNA-135a (miR-135a) in cardiac fibrosis have not been investigated. Here, we explored the regulation mechanism of miR-135a on cardiac fibrosis. In vitro, cardiac fibroblasts (CFs) from neonatal rats were treated by isoproterenol (ISO) at the final concentration of 10 μM for 24 h and miR-135a expression was decreased obviously. A miR-135a mimic inhibited CFs proliferation and differentiation by down-regulating transient receptor potential melastatin 7 (TRPM7) expression and current, whose effects were reversed by either the addition of miR-135a mimic or silencing TRPM7. In vivo, adult SD rat cardiac fibrosis was induced by subcutaneous administration of ISO (5 mg/kg/day) for 10 days. The expression of Collagen I, α-smooth muscle actin (α-SMA) and TRPM7 were up-regulated while miR-135a was down-regulated. In summary, our results illustrated that TRPM7 channel played an essential role in regulating fibrosis and that miR-135a protected against ISO-induced cardiac fibrosis via TRPM7 channel. MiR-135a inhibits cardiac fibrosis v...Continue Reading

References

Mar 1, 1994·Journal of Molecular and Cellular Cardiology·K T WeberJ P Cleutjens
Jan 29, 1999·Physiological Reviews·B Swynghedauw
Dec 20, 2005·The Journal of Membrane Biology·Karl Kunzelmann
Jun 30, 2007·The Journal of Biological Chemistry·Mingjiang LiLixia Yue
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eva van RooijEric N Olson
Nov 17, 2009·Experimental and Molecular Pathology·Weiwei Feng, Weimin Li
Oct 29, 2010·Journal of Physiology and Biochemistry·Yong HuangGuo Zheng Zhang
Feb 11, 2011·Kidney International·Jeffrey L Barnes, Yves Gorin
Nov 6, 2012·Heart Failure Reviews·Ana Maria SeguraL Maximilian Buja
Dec 21, 2012·Journal of Cellular Physiology·Chuanyu WeiSudhiranjan Gupta
Feb 22, 2013·Nature·Reinier A BoonStefanie Dimmeler
May 8, 2013·Cellular and Molecular Life Sciences : CMLS·Ping KongNikolaos G Frangogiannis
Jul 12, 2014·International Journal of Biological Sciences·Zheng DangKe-Feng Dou
Jan 17, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xin ZhaoZhijian Chen
Mar 13, 2015·Molecular Brain·Wenliang ChenHong-Shuo Sun
Mar 31, 2015·Circulation Research·Andrew Leask
Aug 4, 2015·Biochemical and Biophysical Research Communications·Hongyang ShiPing Fang
Aug 22, 2015·Journal of the American College of Cardiology·Mikhail S DzeshkaEduard Shantsila
Jan 27, 2017·International Journal of Biological Sciences·Ning LiuBin Liu
Feb 12, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Eric DuongStanley Nattel

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Citations

Feb 28, 2020·Experimental and Therapeutic Medicine·Shaohua XianZhengfu Zhang
Mar 19, 2019·Frontiers in Physiology·Debora FalcónTarik Smani
Apr 23, 2019·Experimental and Therapeutic Medicine·Yinghui ZhangYingbo Zhang
Jun 4, 2021·Chemical & Pharmaceutical Bulletin·Hui FengYafeng Zhou
Jun 3, 2021·International Journal of Molecular Sciences·Mihir Parikh, Grant N Pierce
Nov 5, 2020·Burns : Journal of the International Society for Burn Injuries·Yan ZhiJia Zhang
Aug 23, 2021·Pathology, Research and Practice·Hui ZhaoJun Yu
Dec 2, 2021·Journal of Physiology and Biochemistry·Hao-Yuan DengHui-Hua Li
Jan 14, 2022·Canadian Journal of Physiology and Pharmacology·Xiao-Xu Yang, Zhen-Yu Zhao

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