MicroRNA-140 regulates cell growth and invasion in pancreatic duct adenocarcinoma by targeting iASPP

Acta Biochimica Et Biophysica Sinica
Shuai LiangYixiong Li

Abstract

MicroRNAs are ∼22 nucleotide RNAs processed from RNA hairpin structures that play important roles in regulating protein expression level via binding to mRNA, either suppressing its translation or speeding up its degradation. In humans, they regulate most protein-coding genes, including genes important in cancer and other diseases. In this study, the expression of microRNA-140 (miR-140) was demonstrated to be significantly suppressed in pancreatic duct adenocarcinoma specimens and cell lines, compared with their adjacent normal tissues. With the help of bioinformatics analysis, inhibitor of apoptosis-stimulating protein of p53 (iASPP) was identified to be a direct target of miR-140, and luciferase reporter experiment confirmed this discovery. Overexpression of miR-140 decreases the protein expressions of iASPP, ΔNp63, MMP2, and MMP9. Growth and invasion of PANC-1 cells were attenuated by overexpression of miR-140 in vitro. The suppressive effect of miR-140 on PANC-1 cell line could be partly balanced out by manual overexpression of iASPP. Above all, these findings provided insights into the functional mechanism of miR-140, suggested that the miR-140/iASPP axis may interfere with the proliferative and invasive property of pancrea...Continue Reading

References

Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Mar 6, 2007·Oncogene·M P Deyoung, L W Ellisen
Mar 30, 2007·Journal of Molecular Biology·Xinwei ZhangJianxiang Wang
Apr 21, 2007·The Journal of Clinical Investigation·Chee-Onn LeongLeif W Ellisen
May 29, 2009·Annals of Surgical Oncology·Soeren Torge MeesJoerg Haier
Jun 2, 2009·Leukemia Research·Sébastien Gillotin
Apr 9, 2011·Oncology Research·Tao LiuChuiZe Kong
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mario NotariXin Lu
Feb 13, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hao YangLianyue Yang
May 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Emmanouel PavlakisSpiros D Ladas
Mar 29, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yujiao JiaJianxiang Wang
Jun 26, 2014·Journal of Experimental & Clinical Cancer Research : CR·Chenchao MaKaixing Ai
Oct 17, 2014·Methods in Molecular Biology·Valentina ProfumoNadia Zaffaroni
Nov 13, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X-L LaiW-P Li
Mar 3, 2015·Seminars in Oncology·Geoffrey KozakJonathan R Brody
Mar 20, 2015·Endoscopic Ultrasound·Pradermchai KongkamPinit Kullavanijaya
Apr 16, 2015·BioMed Research International·Huiyin LanHongchuan Jin

❮ Previous
Next ❯

Citations

Apr 10, 2016·Cellular Oncology (Dordrecht)·V TaucherJ Haybaeck
May 15, 2020·Cancer Biotherapy & Radiopharmaceuticals·Bo YuanJiangong Li
Oct 12, 2019·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Zheng-Zheng LiuYong-Quan Tian
Jul 17, 2019·Journal of Cellular Biochemistry·Shijia ZhaoYan Diao
Dec 16, 2020·Cancers·Lily NguyenStephanie E Combs
May 29, 2021·Environmental Science and Pollution Research International·Marwa M MahmoudNadia M Hamdy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis