microRNA-146a Signaling in Alzheimer's Disease (AD) and Prion Disease (PrD)

Frontiers in Neurology
Walter J Lukiw

Abstract

The mouse- and human-brain-resident, nuclear factor kappa B (NF-κB)-regulated, micro RNA-146a-5p (miRNA-146a-5p) is an inducible, 22-nucleotide, single-stranded non-coding RNA (sncRNA) easily detected in several brain and immunological cell types, and an important epigenetic modulator of inflammatory signaling and the innate-immune response in several neurological disorders. Among all studied microRNAs, miRNA-146a-5p (typically referred to as just miRNA-146a) has been well characterized and its pathological function in progressive, age-related, and lethal human inflammatory neurodegenerative disease states is well documented. This communication will review our current understanding of miRNA-146a, its induction by the NF-kB-stimulating actions of inflammatory mediators, including the secretory products of certain microbial species such as viral vectors, and Gram-negative bacteria (such as Bacteroides fragilis) that are normal residents of the human gastrointestinal (GI) tract microbiome, and how miRNA-146a appears to contribute to neuro-pathological, neuro-inflammatory, and altered neuro-immunological aspects of both Alzheimer's disease (AD) and prion disease (PrD).

References

Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M NeiG Glazko
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Oct 31, 2006·Oncogene·T D Gilmore, M Herscovitch
Aug 27, 2009·Journal of Biomedicine & Biotechnology·Christian BarbatoCarlo Cogoni
Oct 14, 2009·Drug Discovery Today·Reema RoshanBeena Pillai
Apr 14, 2010·Scandinavian Journal of Immunology·L LiY-J Li
Jul 8, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julie A Saugstad
Dec 6, 2011·Experimental Neurology·Walter J Lukiw
Dec 12, 2012·Alzheimer's Research & Therapy·Walter J Lukiw
Aug 20, 2014·Frontiers in Aging Neuroscience·Franc LlorensIsidre Ferrer
Feb 19, 2015·Frontiers in Microbiology·James M HillWalter J Lukiw
Jul 29, 2015·Frontiers in Neurology·Yuhai ZhaoWalter J Lukiw
May 18, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Valeria Calsolaro, Paul Edison
Jan 14, 2017·Cell·Qian ZhangDavid Baltimore
Feb 7, 2017·Current Alzheimer Research·Francesca RegenMarcella Reale
Feb 15, 2017·Cold Spring Harbor Perspectives in Medicine·Julie A Moreno, Glenn C Telling
Mar 16, 2017·Current Neuropharmacology·Marta SochockaJerzy Leszek
Apr 28, 2017·Journal of Sport and Health Science·Walter J Lukiw
Aug 8, 2017·CNS & Neurological Disorders Drug Targets·Chul Ju HwangJin Tae Hong
Aug 26, 2017·International Review of Cell and Molecular Biology·Sean QuinlanEva M Jimenez-Mateos
Sep 25, 2017·Reviews in the Neurosciences·Reihaneh DehghaniNima Rezaei
Dec 24, 2017·Journal of Neural Transmission·Cira Dansokho, Michael Thomas Heneka
Sep 27, 2018·Journal of Neuroinflammation·Estella A NewcombeRodrigo Medeiros
Nov 6, 2018·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mir Hilal AhmadAmal Chandra Mondal
Jan 18, 2019·Viruses·James A Carroll, Bruce Chesebro
Feb 9, 2019·Molecular Neurobiology·S SwarbrickAlexandra Stolzing
Jun 7, 2019·Epilepsy & Behavior : E&B·Elizabeth BrindleyDavid C Henshall
Jul 13, 2019·Human Genetics·Holly E Kinser, Zachary Pincus
Jul 30, 2019·Progress in Neurobiology·Camille A JuźwikAlyson E Fournier
Aug 25, 2019·International Journal of Molecular Sciences·Serena SilvestroEmanuela Mazzon
Sep 25, 2019·International Journal of Molecular Sciences·Valeria D'Argenio, Daniela Sarnataro

❮ Previous
Next ❯

Citations

Sep 25, 2020·Journal of Personalized Medicine·Walter J LukiwYuhai Zhao
Jul 28, 2020·International Journal of Molecular Sciences·Walter J Lukiw, Aileen I Pogue
Nov 17, 2020·Frontiers in Neuroscience·Yuhai ZhaoWalter J Lukiw
Apr 13, 2021·Frontiers in Neuroscience·Mahta MoraghebiPegah Mousavi

❮ Previous
Next ❯

Methods Mentioned

BETA
dot blot
glycosylation
transgenic
gene array

Related Concepts

Related Feeds

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Alzheimer's Disease: RNA Regulation

RNA regulation involves several mechanisms that are used by cells to decrease or increase the production of RNA. Disruption of RNA regulatory processes has been associated with Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA regulation and AD.

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.