MicroRNA-146b-5p inhibits the growth of gallbladder carcinoma by targeting epidermal growth factor receptor

Molecular Medicine Reports
Jingli CaiHai Hu

Abstract

Gallbladder cancer (GBC) is the most common and aggressive type of biliary tract cancer. The study of potential treatments for GBC has recently focused on microRNAs, a class of small non-coding RNAs, which post-transcriptionally regulate gene expression during various crucial cell processes. The present study aimed to investigate the role of microRNA-146b (miR-146b) in GBC. Human GBC tissue and adjacent normal gallbladder tissue sections were surgically removed and miR-146b-5p expression and the development and pathological characteristics of GBC were investigated. miR-146b-5p expression was reduced in GBC tissue compared with that in adjacent tissue, and a significant correlation was observed between miR-146b-5p expression levels and carcinoma size and development. miR-146b-5p overexpression in the SGC-996 GBC cell line inhibited cell growth through enhanced apoptosis and G1 phase arrest. Furthermore, it was demonstrated that epidermal growth factor receptor (EGFR) was regulated directly by miR-146b-5p and was essential as a mediator of the biological effects of miR-146b-5p in GBC. Enforced expression of EGFR reversed the ability of miR-146b-5p to inhibit proliferation. In conclusion, the present study indicated that the mecha...Continue Reading

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Citations

Nov 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Chen-Kai ChouHong-Yo Kang
Feb 9, 2016·World Journal of Gastroenterology : WJG·Vishal ChandraRajani Rai
Jun 23, 2016·Molecular and Clinical Oncology·Ganghua YangLin Wang
Jan 25, 2017·Gastroenterology Research and Practice·Nina Nayara Ferreira MartinsDanielle Queiroz Calcagno
Dec 12, 2018·Blood Advances·Takahiro MitsumuraHiroshi Asahara
Aug 7, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Le ZhangYanping Wang
Nov 26, 2020·The Kaohsiung Journal of Medical Sciences·Xiang-Lu LiXue-Hua Xing
May 4, 2021·Seminars in Cell & Developmental Biology·Raza Ali NaqviAfsar R Naqvi

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