MicroRNA-153 inhibits osteosarcoma cells proliferation and invasion by targeting TGF-β2

PloS One
Guangfeng NiuChenggong An

Abstract

Increasing evidence indicates that microRNAs (miRNAs), a class of small noncoding RNAs, participate in almost every step of cellular processes. MiRNAs are aberrantly expressed in human cancers and contribute to cancer development and progression. Study of miRNAs may provide a new clue for understanding the mechanism of carcinogenesis and a new tool for cancer treatment. In the present study, miR-153 was downregulated in human osteosarcoma tissues and cell lines. Introduction of miR-153 mimics into the MG-63 cells inhibited cell proliferation and invasion. Our results further revealed that transforming growth factor beta 2 (TGF-β2) was negatively regulated by miR-153. Furthermore, overexpression of miR-153 decreased p-SMAD2, p-SMAD3, epidermal growth factor receptor (EGFR) and insulin-like growth factor binding protein-3 (IGFBP-3) expressions, which were the downstream signaling molecules of TGF-β. Furthermore, miRNA-153 suppressed TGF-β-mediated MG-63 proliferation and migration. Therefore, our results suggest that miR-153 may act as a tumor suppressor in osteosarcoma through targeting TGF-β2.

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Citations

Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chen LvGuanjun Tu
Jan 29, 2016·Journal of Inorganic Biochemistry·Stefan NikolićSanja Grgurić-Šipka
Mar 5, 2016·Biochimica Et Biophysica Acta·Ghazala Mustafa, Setsuko Komatsu
Jul 29, 2015·Experimental and Molecular Pathology·Chunlian LiangWeilin Yang
Aug 12, 2016·PloS One·Peng WangDaling Zhu
Feb 22, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhenyang LiuRuxiang Xu
Mar 5, 2018·Journal of Cellular and Molecular Medicine·Lihua YanXunmeng Ding
Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
Dec 29, 2018·Journal of Cellular Biochemistry·Lihua YanWenfeng Xian
Jan 19, 2019·Oncology Letters·Guangliang GuoXue Bian
Oct 18, 2020·International Journal of Molecular Sciences·Jessica JannNathalie Faucheux
May 1, 2021·Biomedicines·Lola Llobat, Olivia Gourbault

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Methods Mentioned

BETA
PCR
transfections
Assay
transfection

Software Mentioned

SPSS

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