MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis.

Cell Death & Disease
Weigang ZhangChunying Li

Abstract

Keratinocytes are the main epidermal cell type that constitutes the skin barrier against environmental damages, which emphasizes the balance between the growth and the death of keratinocytes in maintaining skin homeostasis. Aberrant proliferation of keratinocytes and the secretion of inflammatory factors from keratinocytes are related to the formation of chronic inflammatory skin diseases like psoriasis. MicroRNA-17-92 (miRNA-17-92 or miR-17-92) is a miRNA cluster that regulates cell growth and immunity, but the role of miR-17-92 cluster in keratinocytes and its relation to skin diseases have not been well investigated. In the present study, we initially found that miR-17-92 cluster promoted the proliferation and the cell-cycle progression of keratinocytes via suppressing cyclin-dependent kinase inhibitor 2B (CDKN2B). Furthermore, miR-17-92 cluster facilitated the secretion of C-X-C motif chemokine ligand 9 (CXCL9) and C-X-C motif chemokine ligand 10 (CXCL10) from keratinocytes by inhibiting suppressor of cytokine signaling 1 (SOCS1), which enhanced the chemotaxis for T lymphocytes formed by keratinocytes. In addition, we detected increased expression of miR-17-92 cluster in psoriatic lesions and the level of lesional miR-17-92...Continue Reading

References

Oct 1, 1989·Physiological Reviews·R L Eckert
Jun 21, 2011·Immunological Reviews·Mark Boguniewicz, Donald Y M Leung
Sep 28, 2012·The British Journal of Dermatology·A HaldC Johansen
Dec 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ning XuEnikö Sonkoly
Apr 19, 2013·Nature Reviews. Molecular Cell Biology·Frederick A Dick, Seth M Rubin
May 11, 2013·Archives of Oral Biology·Márcia Rodrigues PayerasFernanda Gonçalves Salum
Nov 7, 2013·Physiological Genomics·Qing CaoTing-Ting Huang
Feb 28, 2014·Science Translational Medicine·Juan Guinea-ViniegraErwin F Wagner
Mar 25, 2014·Annual Review of Immunology·Michelle A LowesJames G Krueger
Apr 8, 2014·Cellular and Molecular Life Sciences : CMLS·Julhash U KaziLars Rönnstrand
Apr 20, 2014·RNA·Yu FanJianzhong Jeff Xi
Aug 6, 2014·Immunology·Bart-Jan KroesenJoost Kluiver
Jul 18, 2015·Cancer Discovery·Andrew S McNealTodd W Ridky
Nov 12, 2015·Nature Communications·Marija MihailovichTiziana Bonaldi
Feb 4, 2016·Circulation Research·Jan Fiedler, Thomas Thum
Mar 16, 2016·Journal of Dermatological Science·Sohshi MorimuraShinichi Sato
Aug 19, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nahid AkhtarSalahuddin Ahmed
Oct 30, 2016·Trends in Plant Science·Natalia P AchkarPablo A Manavella
Dec 10, 2016·Frontiers in Immunology·Gajendra M JogdandSatish Devadas
May 4, 2017·Biochemical and Biophysical Research Communications·Qinghua JiaLisheng Wang
Sep 10, 2017·The Journal of Allergy and Clinical Immunology·Jason E HawkesJames G Krueger
Sep 16, 2017·Current Opinion in Immunology·Kenji Kabashima, Takashi Nomura
Nov 8, 2017·Proceedings of the National Academy of Sciences of the United States of America·A E GetschmanB F Volkman

❮ Previous
Next ❯

Citations

Sep 8, 2020·The Journal of Gene Medicine·Weisheng WangYong Li
Oct 17, 2018·International Journal of Molecular Sciences·Mirco Di MarcoRosa Visone
Oct 16, 2019·Frontiers in Immunology·Haijing WuQianjin Lu
Oct 16, 2018·Frontiers in Medicine·Paula T KuoGraham R Leggatt
Aug 19, 2020·International Journal of Molecular Sciences·Ai-Young Lee
Aug 23, 2020·Dermatologic Therapy·Sai PradyuthGautam Singhvi
Sep 20, 2020·The Journal of Investigative Dermatology·Dongqing LiNing Xu Landén
Mar 24, 2021·Experimental Dermatology·Chang ZengJohann E Gudjonsson
Jun 24, 2021·Journal of Cellular Physiology·Kehinde Ross
Aug 18, 2021·The FEBS Journal·George BibbyKehinde Ross
Oct 28, 2021·American Journal of Clinical Dermatology·Ana Maria Lé, Tiago Torres
Nov 13, 2021·Journal of Biochemical and Molecular Toxicology·Nevin IlhanIbrahim H Ozercan

❮ Previous
Next ❯

Methods Mentioned

BETA
transfections
transfection
enzyme-linked immunosorbent
ELISA
immunoprecipitation
PCR
biopsy
circumcision
Fluorescence
flow cytometry

Software Mentioned

Targetscan
Expo32
GraphPad Prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.