MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Xiangyang ZhangYuyuang Li

Abstract

MicroRNAs have emerged as crucial regulators of tumorigenesis. However, it remains unknown whether miR-181a is involved in the pathogenesis of gastric cancer. In this study, we found that miR-181a is overexpressed in human gastric cancer tissues. Ectopic expression of miR-181a mimic promoted the proliferation, colony formation, migration, and invasion and inhibited the apoptosis of SGC-7901 gastric cancer cells, whereas ectopic expression of miR-181a inhibitor inhibited the malignant phenotypes of SGC-7901 cells. Site-directed mutagenesis and luciferase reporter assay demonstrated that miR-181a repressed KLF6 expression by targeting its 3'-UTR. Western blot analysis further showed that KLF6 protein was significantly decreased or increased when miR-181a mimic or inhibitor was transfected into SGC-7901 cells, respectively. In summary, these data suggest that KLF6 gene is a direct target of miR-181a and miR-181a functions as an oncomir in gastric cancer by repressing the expression of tumor suppressor KLF6.

References

Jun 26, 2001·Journal of Cellular Physiology·A R BlackJ Azizkhan-Clifford
Jul 10, 2001·The Journal of Biological Chemistry·J J Bieker
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 26, 2003·The American Journal of Pathology·Ceshi ChenJin-Tang Dong
Mar 5, 2004·Cancer Cell·Toshikazu Ushijima, Mitsuru Sasako
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sigal Kremer-TalScott L Friedman
Apr 13, 2005·Oncogene·Yong Gu ChoWon Sang Park
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jul 26, 2005·Biochemical and Biophysical Research Communications·S A CiafrèM G Farace
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Analisa DiFeoJohn A Martignetti
Jul 29, 2006·Journal of Gastroenterology and Hepatology·Jaehwi SongWon Sang Park
Mar 9, 2007·Genes & Development·Joel R NeilsonPhillip A Sharp
May 22, 2007·International Journal of Cancer. Journal International Du Cancer·Olga Camacho-VanegasJohn A Martignetti
Oct 2, 2007·The International Journal of Biochemistry & Cell Biology·Richard PearsonShisan Bao
Nov 21, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Laia AgellJosep Lloreta
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jaya SangodkarGoutham Narla
Feb 11, 2010·Cancer Research·Lorenzo GalluzziGuido Kroemer
Dec 21, 2010·Biochemical and Biophysical Research Communications·Ki-Hyuk ShinNo-Hee Park
Nov 15, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lili LiuHelong Zhang
Nov 17, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Heba W Z KhellaGeorge M Yousef

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Citations

Jan 17, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhu JianweiAn Ning
Jun 7, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhu JianweiLi Can
Nov 21, 2012·Nature Reviews. Gastroenterology & Hepatology·Shumei Song, Jaffer A Ajani
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaolu A CambronneRichard H Goodman
Aug 20, 2014·Nature Reviews. Gastroenterology & Hepatology·Mairi H McLean, Emad M El-Omar
Sep 19, 2014·Acta Biochimica Et Biophysica Sinica·Zhengkai XiangBaoguo Yan
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chen LvGuanjun Tu
Sep 20, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Peyman Karimi GoudarziAlireza Mirghasemi
Mar 1, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Jennifer BrockhausenGeoff W McCaughan
Mar 6, 2015·Leukemia Research·Lorena VerduciGiuseppe Macino
Jan 11, 2019·Molecular Medicine Reports·Dongming LuoPengcheng Yu
Oct 2, 2020·Biomolecules·Saiful E SyafruddinTeck Yew Low
Jul 22, 2017·Medical Oncology·Venkateshwarlu Bandi, Sudhakar Baluchamy
Jan 4, 2020·Journal of Gastric Cancer·Haiyang YangZhengjiang Qian
Oct 19, 2013·Oncology Letters·Xiaohui XuJianping Cao
Oct 29, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liucheng WuYuan Lin
Dec 23, 2020·Cancers·Anantha MarisettyAmy B Heimberger
Mar 10, 2021·In Vitro Cellular & Developmental Biology. Animal·X LiL Lian

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